DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	265/533 - (49%)
Similarity:	362/533 - (67%)	Gaps:	22/533 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVGRTKSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPT 65
            |:|   .:||.:|.|. ::...|||||||||.|.|||||||.|||||.|.:.|||||||::|:|.
  Fly     1 MIG---VHFVFLLLLG-VVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPK 61

  Fly    66 ITHKNINLVTVPMTKEE--IKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRV 128
            :|||:|:|:.|||.:|:  |.:...|..|.|||:..:....:|.   .||.|:...|::|.|.|.
  Fly    62 VTHKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLT---SMDVMINAQAELLSDPRF 123

  Fly   129 KELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHD-------KV 186
            :.:|..|   |||:|.|||:||:|||.|.|:..||::...|.|...::...|||.:       ..
  Fly   124 QRIYETK---FDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGT 185

  Fly   187 EKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHA 251
            ...:.|.|.:|.::.:.|||:.......|.:..:.||::| .:..||...::.:|.|:.|..||.
  Fly   186 VATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVF-PEQDMPTLKELRKNISMAFVGSHL 249

  Fly   252 ASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHIKADTVKKI 316
            .|||||||.|||.|||||||:|||||||||::::|:.||..||:.|||||||:.|.::.:.|:.|
  Fly   250 ISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQII 314

  Fly   317 FSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGK 381
            |.|||.||:.|||||:||:.|||.|.||||..|||||||||||:.||||.|||||||:||||||.
  Fly   315 FKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGV 379

  Fly   382 PMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRP 446
            ||::||:||||||||..|.|||:||.|.||::.|:..|.|:.|:|.|.||.|.:.:||:||||||
  Fly   380 PMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRP 444

  Fly   447 ASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRR 511
            .:|::|::|||||::||.||.:||||.|||:||..|||||||||..|.:..:|:.:.|.:|...:
  Fly   445 MTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNK 509

  Fly   512 L--RTKLNKVKKQ 522
            .  :.|:::.||:
  Fly   510 FGGKAKISQTKKK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	223/439 (51%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	240/476 (50%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	244/488 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445658
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	10.000