DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	177/548 - (32%)
Similarity:	276/548 - (50%)	Gaps:	69/548 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SYFVIVLALTLLIYG-AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKN 70
            |:.:::|||    :| :.|.:.|.:..:.|.||..:..::||.||..||.||:|:........||
  Fly     7 SWLLLILAL----FGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKN 67

  Fly    71 I------NLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSM-LRKMADVLKDQRV 128
            |      |::||             :|..:.....|....:|....::..| |.....:||:.:|
  Fly    68 IIDVETPNIITV-------------MGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKV 119

  Fly   129 KELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLA--------------PSPPSQMLNSLI 179
            :|| |.::..||.||...||||...|||....||::.|:              |||||.:.:||
  Fly   120 QEL-LKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSL- 182

  Fly   180 GNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQID-------QRNRQYYNEIFGDDPTMPEYTD 237
                        :.||.|::.:..:...|..:.:..       .|:...|.:.|.::  ..::..
  Fly   183 ------------LRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNN--KQDFYR 233

  Fly   238 ILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDK-PDPLPKNLEKFLGNATHGAILLSLGS 301
            :.::||||...:|.:...| ||..|..||:||:.:..| |.|||:|:.||:..|.||.|..||||
  Fly   234 MRKDTSLVLLNNHVSISNP-RPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGS 297

  Fly   302 NVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFIN 366
            |:....:..:..|.|...|..||.|||||::: :....|.||:|.|.||||||||||..|..||.
  Fly   298 NLNSKDLPENKRKAIVETLRGLKYRVIWKYEE-ETFVDKPDNVLISNWLPQDDILAHEKVIAFIT 361

  Fly   367 HAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKY 431
            |.|.....|:.|||||::.:|.||||..|.....:.|:|:|:....|....||:|:..|.|:|.:
  Fly   362 HGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSF 426

  Fly   432 SQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDI----YALIGA 492
            ::||...||.|||:..:..|..::|.|:|.||.||.:|:|....::||..:|||:    :::||.
  Fly   427 TERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGL 491

  Fly   493 ISIGLLLMLKKVVQITCRRLRTKLNKVK 520
            ..|.:.|:::.:|.|....|....:|:|
  Fly   492 TVIFVFLLVRFLVTIVNGFLYKPSSKLK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	148/459 (32%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	131/367 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445732
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950