DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	161/533 - (30%)
Similarity:	262/533 - (49%)	Gaps:	47/533 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVT---VLEPTITHKNI 71
            :|||.:.||....:||.|||:||..|.||...::...|.||..||.:|.|:   :.||.   .||
  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPV---ANI 71

  Fly    72 NLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSM-------LRKMADVLKDQRVK 129
            :.:.||...:.|:   |.:|            ::.|..|..:..       |..:..||::..|:
  Fly    72 HDIPVPELFDNIE---EIVG------------NLTNRKGTWNEFEYINQYTLGLVEKVLENDGVR 121

  Fly   130 ELYLNKDN-HFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHDKVEKEKGM- 192
            ...|..:: .|||:|...:..|...|.|...:||::.:|.......::.|:||.......:...
  Fly   122 REILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSF 186

  Fly   193 ------TFGQRLDSYI-SSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSH 250
                  |:|.||..:: .|:.:..:..:.::|:...|.:.|.........::|.||.:|:....|
  Fly   187 NWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQH 251

  Fly   251 AASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVK 314
             .:..|.||.||..||:||:.:..:|..||::||.|: |...||.|..|||:||:..::..|..|
  Fly   252 -FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRK 315

  Fly   315 KIFSVLSNLKQRVIWKW--DDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQ 377
            .:....::|.||::||:  |:|...|   .|:|.|.|.||.||||||:|||||.|.|.....|..
  Fly   316 ILIDTFASLPQRILWKFDADELSDVP---SNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECI 377

  Fly   378 YHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLY 442
            :.|.|||.||.|.||..|...:...|.||.|:...:..:.|:..:.::|:...:..:..:.:..|
  Fly   378 HRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRY 442

  Fly   443 RDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQI 507
            ||:|.:..::.|:||.||:||.||.|::....::|||..::||:   :|...:.:..:|..||..
  Fly   443 RDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDV---LGTFLLAVWAILSIVVLC 504

  Fly   508 TCRRLRTKLNKVK 520
            ..:.||..|...|
  Fly   505 AIKLLRAILKSKK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	133/452 (29%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	146/479 (30%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	127/435 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445735
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950