DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	153/543 - (28%)
Similarity:	250/543 - (46%)	Gaps:	69/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALTLLIYG------AQGANILGLFP-SLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKN 70
            |.||:|::|      ....|||.:|. :...|:|:|: ...:.|.::||.:|:::.:......:.
  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLIT-PFLRNLVQRGHQLTLISAVTIMPHIEG 73

  Fly    71 INLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMAD-------------- 121
            ::.:.||                    ..:..:.|| :..:.|:.|.|..:
  Fly    74 VHHIRVP--------------------KLDMLMKIL-LDFEYDTDLTKWTEAQFLSEYFYNCSKF 117

  Fly   122 VLKDQRVKELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHDKV 186
            ||:|..|:||..|....:.|:|.....||...||::..|||::.:|....|..::.|:||....|
  Fly   118 VLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSV 182

  Fly   187 EKEK---GMTFGQRLDSYISSLLY---------GIFL-RQIDQRNRQYYNEIFGDDPTMPEYTDI 238
            .:..   |.|.|..|.....:|:|         .|:| ||||     .|.:.|....|  ...|:
  Fly   183 YEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQID-----LYKQHFPGATT--SIHDL 240

  Fly   239 LRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNV 303
            .|..|||....| .:.|.:|.:||..:|:.|:.:.:||.||...|:|.|..|.||.|..|:|..:
  Fly   241 RRRFSLVLINQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQL 304

  Fly   304 QGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHA 368
            ....:.......:....:.|||:|||| .|..:...:|.|:....|.||..||.||:|||||.||
  Fly   305 LDHWLPPGMRASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHA 368

  Fly   369 GKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQ 433
            |...:.|:.::..|:|.:|:|.||..|...|.|.|....|....|..:....|:.:::.|..|.:
  Fly   369 GLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKR 433

  Fly   434 RVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYA-LIGAISIGL 497
            .....|..:.|:|.||.::.|:||||::||.||.|::.....|..:...|:|:.: |.|.|.:..
  Fly   434 NARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSA 498

  Fly   498 LLML---KKVVQITCRRLRTKLN 517
            ::::   .|:|.:..|.|..:||
  Fly   499 IIVIFLGWKLVSLATRHLEYRLN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	127/458 (28%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	133/469 (28%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	138/498 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445728
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950