DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt304A1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	142/519 - (27%)
Similarity:	248/519 - (47%)	Gaps:	43/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHK--NINLVTVPMTKEEIKQ 85
            :.:.||.:.|..|.|..::.....:.|.::||.:||:...:..: ||  ::..:.:........:
  Fly    23 RSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCM-HKIEDVTFIRIWYNNNVFLE 86

  Fly    86 RSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKELYLNKDNHFDLVI--SGYFM 148
            ..|::|....|   |::..|.:||   ..|.....:||.:..|:.|..::.. ||.|:  :||
  Fly    87 FEESVGIASAN---NKWEEISSMS---SLMANATLNVLNNVEVRALMKSRIT-FDAVVLEAGY-- 142

  Fly   149 NDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYG----- 208
            :|...|.|...:|.::.:........:|:|:|.....: .|..|.|..:....:...:|.
  Fly   143 SDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTL-TEPIMPFRAKYVKNVWDRIYNWLYTT 206

  Fly   209 --------IFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAI 265
                    :||    .:.|..::..||.  ....:.:|.::.:|:....| .|....||:||..:
  Fly   207 EEWLLINLVFL----PKQRLIHDHFFGH--LEKSFHEIRQDFALMLLNQH-FSLFRARPNVPGMV 264

  Fly   266 EIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWK 330
            |:.|:.|..:...||.:|:.|:..|.||.||.|||.......:...|.:.:.....::.||||||
  Fly   265 EVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWK 329

  Fly   331 WDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGN 395
            :|. :.|.....:|.:|:.|||..|||||:|||||:|.|...:.||.|:.||:|.||.|.||..|
  Fly   330 FDG-ESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRN 393

  Fly   396 AHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYV 460
            ...|.:.|..|.|::.:|..:..:.|:..:::.|:|.:..:..|..:||:|....::.|:||||:
  Fly   394 LEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYI 458

  Fly   461 IRHHGAAHL---QSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            ||:.||.|:   ||.|...|:.   :||.:.::|: .:.|::.|..:|....||....|:...|
  Fly   459 IRYKGADHMKISQSQLKLFDYY---SLDNFIMVGS-RLSLVVALVFLVLSKSRRWLNHLSTSAK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	119/447 (27%)
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	132/475 (28%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	112/421 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445730
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950