DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	164/529 - (31%)
Similarity:	263/529 - (49%)	Gaps:	39/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT 75
            |.|.:.||...::||.||.:||..|.||...::...|.||..||.:|.|:........:||:.:.
  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68

  Fly    76 VPMTKEEIKQRSETIGAKQKNTSSNRFIS--ILNMSGQMDSMLRKMADVLKDQRVKELYLNKDN- 137
            ||...|...:........:....|:.||:  :||::          ..||.::.|:...|....
  Fly    69 VPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLT----------KTVLNNEGVRRDILGPQKP 123

  Fly   138 HFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGN--PHDKVEKEKGMTFGQRLDS 200
            ||||||...:..|...|.|...:||::.:|.......::.|:||  |...::......:.  |::
  Fly   124 HFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRFYD--LEA 186

  Fly   201 YISSLLYGIFLRQIDQRNRQY---------YNEIFGDDPTMPE---YTDILRNTSLVFFCSHAAS 253
            |...||: :..|.....|.::         |::.|   |::.|   .::|.||..||....| .:
  Fly   187 YGERLLH-LMERTFSYMNYKWRHVRKQETLYSQFF---PSVAERKPLSEISRNFDLVLVNQH-FT 246

  Fly   254 EGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVKKIF 317
            .||.||.||..|::||:.:....:.|...|:.|: |....|.|..|||:||:...:..|..|.:.
  Fly   247 LGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLL 311

  Fly   318 SVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKP 382
            ...::|.||::||::| :..|||..|:..|:|.||..|||||:|||||.|.|.....|:.:||||
  Fly   312 ETFASLPQRIVWKFED-ELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKP 375

  Fly   383 MLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPA 447
            ||.||...||..|...:.:.|.||.|::..:..|.||:.::.:|:|..:.:.....::.|||:|.
  Fly   376 MLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPM 440

  Fly   448 SARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRL 512
            ...|:.|:|||||:.|.||||:|.....:.|:..::||::   |...:|.|::|..|..:....|
  Fly   441 KPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVF---GTFLVGALVILGIVTYLLVMTL 502

  Fly   513 RTKLNKVKK 521
            |..|..:|:
  Fly   503 RKCLFLIKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	136/448 (30%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	150/475 (32%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	152/501 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445736
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950