DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt303B3

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	153/563 - (27%)
Similarity:	259/563 - (46%)	Gaps:	108/563 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YFVIVLALTLL---IY--GAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTIT 67
            |::.||....|   :|  ..|.|||||:|.....||.::...:||.|.::|||||::|.:.....
  Fly     6 YWLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTD 70

  Fly    68 HKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKM-ADVLKDQRVKEL 131
            .:.:..:.||...:.:::..|  |.:..:...:::|:.|    .:.|||..| :|:|.|:.|:::
  Fly    71 IEGVRHIRVPKLNQRVQEMIE--GDQILDFFGSKWIASL----MVVSMLYNMSSDILSDKGVQKM 129

  Fly   132 YLNKDNHFDLVI-----------------------SGYFMN----DYQLGFARKVNAPVVVLAPS 169
            ..|::..||||:                       ||..:|    :....||..:|.|:..|..|
  Fly   130 LQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYS 194

  Fly   170 PPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLY-----GIFLRQIDQRNRQYYNEIFGDD 229
            ..:.:|:.:....|...||            .:..|::     .||.:..:...:::||
  Fly   195 RSNSLLSKIYNWVHITEEK------------LLKHLIFRPSQLRIFKKFFNFSEQKFYN------ 241

  Fly   230 PTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGA 294
             ...:|:.||.|..:        |.|.:|.:||..||:||:.:.:..:|....|:||:.:|.||.
  Fly   242 -MREKYSVILVNNHI--------SMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDAEHGV 297

  Fly   295 ILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHP 359
            |..|:|..:....:..|..:.:...|...||||:|| .:|...|.||||:......||..:||||
  Fly   298 IYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWK-TELYNMPNKSDNVYVIEQPPQRAVLAHP 361

  Fly   360 SVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAH-------AMVKSGFGLTLSLLTLEEEP 417
            :.:|||.:.|...:.||.|.|.|:|.||||.||..|..       |.|.....:||.:||
  Fly   362 NTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILT----- 421

  Fly   418 FRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAAN 482
              :.:.::|.||:|:.:..|.|..:||||.|..::.::||||.:|:..|:|::          .|
  Fly   422 --STIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMR----------LN 474

  Fly   483 NLDI-------YALIGAISIGL-----LLMLKKVVQITCRRLR 513
            ..|:       :.|:..:..|:     :.::.|:.|.|..|.|
  Fly   475 TEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYKLFQKTSARRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	131/470 (28%)
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	141/499 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445726
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950