DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	166/541 - (30%)
Similarity:	281/541 - (51%)	Gaps:	45/541 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINL 73
            |:.:|.:.||..| .||.||..|.....||.:::.::.:.|.::||.||.:|.|  ::..:|:.
  Fly     4 FMKLLFVCLLGTG-DGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPL--SLAKENLG- 64

  Fly    74 VTVPMTKEEIKQRSET---IGAKQKNTSSNRFISILNMSGQMDSMLR-----KMAD-VLKDQRVK 129
               |..:|.:..:.:|   |.|..|..|:   :.:::||......|.     |..| .|....|:
  Fly    65 ---PNYREILLPKYDTWADISAMMKTKSA---LDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQ 123

  Fly   130 ELYLNKD--NHFDLVISGYFMND--YQLGFARKVNAPVVVLAPSPPSQMLNSLIG--NPHDKVEK 188
            ||...||  ..|||::...|.|:  ..||:..::  |.:.:|....:...:.:.|  ||...|..
  Fly   124 ELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEI--PAITIATFAYANYFSQVFGFVNPLSYVPN 186

  Fly   189 -----EKGMTFGQRLDSYISSLLYGI-----FLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTS 243
                 ...|:..:||::.:.|....:     :..|.|...|::::.:.   |.:|....:.:|.|
  Fly   187 VFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLL---PRVPTVKQLEQNIS 248

  Fly   244 LVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHI 308
            ::...|:.....| ||.....|.:||:.|. .|.|||::::.:|.||.||||..||||.|:.:.:
  Fly   249 VILLNSYMPLTSP-RPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADM 311

  Fly   309 KADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGI 373
            .|:.::....|.::|||||:||::| |:.|...||:...:||||.||||||:||:||.|.|..|:
  Fly   312 PAEKLQIFLDVFASLKQRVLWKFED-DQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGM 375

  Fly   374 SEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKF 438
            .||.||..|:|.:|.:.||..|..|...:|:.:.|...|:.::..::|:..:|.:|||...::|.
  Fly   376 QEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKA 440

  Fly   439 SSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKK 503
            |.::||||..|.::.::|..||:.|.||.||.:..||:.:.....||:.|:|.||::..||.|..
  Fly   441 SRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYA 505

  Fly   504 VVQ--ITCRRLRTKLNKVKKQ 522
            |.:  .:.|.:|.:..:.|.:
  Fly   506 VSRNYKSFRGIRAQKKEAKTE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	137/455 (30%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	160/515 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	149/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454755
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940