DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	273/565 - (48%)	Gaps:	84/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GRTKSYFVIVLAL--TLLIYGA---QGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVL 62
            |..::.||..|.|  .|.::.:   |...:| :.| :..||.:....:.:.::.:||.:.|:...
Zfish    10 GMKRTLFVPALGLFAFLCLFSSESVQAGKVL-VMP-VDGSHWLSMKILVEEMSSRGHEMVVLVPE 72

  Fly    63 EPTITHKNINLVT----VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSG---QMDSMLRKMA 120
            ...:..|:.|..|    ||.:.:|:....:.| .|.....:.|||.|:...|   |..:|..|..
Zfish    73 TSILIGKSGNFTTKSFRVPYSFDELNAHVDHI-RKTAIEKAPRFIDIVGALGNLIQFTNMQVKAC 136

  Fly   121 D-VLKDQ-RVKELYLNKDNHFDLVIS------GYFMNDY----QLGFARKVNA---PVVVLAPSP 170
            : :|.|: .:|.|   :|..||.:::      |..:.||    .:.|.|.:..   ......|||
Zfish   137 EGLLYDEPLMKSL---RDMKFDALLTDPFLPCGSVIADYFSIPAVYFLRGIPCRLDEAAAQCPSP 198

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRL--------DSYISSLLYGIFLRQIDQRNRQYYNEIFG 227
            ||.:.....|.. ||      |||.||:        :.|:...|:..|    |:...:|..:
Zfish   199 PSFIPRFFTGYT-DK------MTFPQRMINTFMTVFEKYLCHQLFASF----DELATRYLKK--- 249

  Fly   228 DDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNAT 291
             |.:   |.::|.:.::.......:.|.| :|.:|..::||||... |..||.|.||:|: |:..
Zfish   250 -DTS---YAELLGHGAVWLLRYDFSFEYP-KPQMPNMVQIGGINCA-KRAPLTKELEEFVNGSGE 308

  Fly   292 HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKS-DNILYSRWLPQDDI 355
            ||.::.:|||.|  |.:.....::.|.....:.|||:|::  ....|..: .|:...:||||:|:
Zfish   309 HGFVVFTLGSMV--SQLPEAKAREFFEAFRQIPQRVLWRY--TGPVPENAPKNVKLMKWLPQNDL 369

  Fly   356 LAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRA 420
            |.||.|:.|:.|.|..||.|...:|.||:.||:||||..||..:|..|...:|::..:..|....
Zfish   370 LGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLV 434

  Fly   421 AVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNL 484
            |:.:::::..|.::::|.|:::||||....:..:||||:|:||.||.||: |..| :::|..::|
Zfish   435 ALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLR-PAAHDLNWIQYHSL 498

  Fly   485 DIYALIGAISIG-LLLMLKKVVQIT------CRRLRTKLNKVKKQ 522
            |:        || |||:|..|:.:|      |.|...|.::.||:
Zfish   499 DV--------IGFLLLILLTVIFVTVKSCMFCFRKCFKKSQKKKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	124/462 (27%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	149/525 (28%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	88/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910