DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	130/514 - (25%)
Similarity:	237/514 - (46%)	Gaps:	49/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQ--GHNVTVVT--------------VLEP 64
            |||.....|||:|.:|||:..||.:....:.:.|.|.  .|:||:::              :.|.
  Fly    10 TLLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQEGVDAEIPKIREL 74

  Fly    65 TITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVK 129
            .|.....|.:.:.|:.|..:.|::::        ..||..::........:|      |.|.:|:
  Fly    75 RIEGLRENWLDMGMSFEAEEMRAQSV--------MERFTRLIYAGTTNVDIL------LSDPQVR 125

  Fly   130 ELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPH-DKVEKEKGMT 193
            :| |.....|||:|...|::|..||.|.....|.|.::|:..:..||::.|||. ..::....:.
  Fly   126 KL-LTSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLP 189

  Fly   194 FGQR-------LDSYISS---LLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFC 248
            |.:|       |:|.:|:   |.|. |...|.|:: .|.|........:|.|.|:.:|.||....
  Fly   190 FTERMNTRQRILNSLMSTFERLTYN-FFHLISQQS-VYTNHFELLVKELPLYRDLTKNLSLALIN 252

  Fly   249 SHAASEGPIRPSVPAAIEIGGIQIKD-KPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHIKADT 312
            ||.....| |..:|..:|:||:.:.. ..|.|||:|..|:.:|..|.|..|||::|:.:.:..:.
  Fly   253 SHPGLHYP-RAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESAPSGVIYFSLGADVETAQLPQEK 316

  Fly   313 VKKIFSVLSNLKQ-RVIWKWDDLDKTPGK--SDNILYSRWLPQDDILAHPSVKLFINHAGKGGIS 374
            :..|..|..:||: ..:.||:..:.|..:  .:|::.:.|.||..||.||.||:||:..|:..:.
  Fly   317 LAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVW 381

  Fly   375 EAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFS 439
            |:....||:|::|:..:|...|..:.:.|..:|:...:|..:.....:.::..|..|.:::.:..
  Fly   382 ESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLK 446

  Fly   440 SLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLL 498
            .....|.::.....:...:.::...||..|:|....::|..|..:|:..:|.....|:|
  Fly   447 ERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFGIL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	116/461 (25%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	124/487 (25%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	107/426 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445737
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950