DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	154/566 - (27%)
Similarity:	251/566 - (44%)	Gaps:	110/566 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT- 75
            :|.|...:..|:|..:| :|| :..||.:....|.:.|..:||. .||...|.|:..|..:..|
  Rat    13 LLLLLCALPWAEGGKVL-VFP-MEGSHWLSMRDVVRELHARGHQ-AVVLAPEVTVHIKEEDFFTL 74

  Fly    76 ----VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKELYLN-- 134
                ||.||||  .|...:|..| |.....|        .:..:|::||.|   ..|...|:.
  Rat    75 QTYPVPYTKEE--YRHHLLGHLQ-NFFETEF--------SLKLVLQRMAAV---NNVSTFYVRSC 125

  Fly   135 -------------KDNHFDLVISGYFMNDYQLG--FARKVNAPVVVL--------------APSP 170
                         ..:.||:|::..|   :..|  .|..:..|.|..              :|:|
  Rat   126 RGLLHNTALIQSLNSSSFDVVLTDPF---FPCGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNP 187

  Fly   171 PSQMLNSL-IGNPHDKVEKEKGMTFGQRLDS--------YISSLLYGIFLR-QIDQRNRQYYNEI 225
            .|.:...| :.:.|        |:|..|:.:        |:..:.||...| ..|...|:.
  Rat   188 SSYIPRLLTLNSDH--------MSFLDRVKNMLYPVPWMYLCHVNYGSLARLASDLLQREV---- 240

  Fly   226 FGDDPTMPEYTDILRNTSL-------VFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNL 283
                    ...:|||:.|:       ||:..        ||.:|..:.||||...:: .||.:..
  Rat   241 --------SVVEILRHASVWLLRKDFVFYYP--------RPFMPNMVFIGGINCANR-KPLSQEF 288

  Fly   284 EKFLGNAT--HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILY 346
            |.:: ||:  ||.::.||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:.
  Rat   289 EAYV-NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTIL 349

  Fly   347 SRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLL 411
            .:||||:|:|.||..:.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|
  Rat   350 VKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVL 414

  Fly   412 TLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH- 475
            .:..:....|:..:::|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..|
  Rat   415 EMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHD 478

  Fly   476 MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :.:...::||:...:.||.:.::.::.|.....||:......:|||
  Rat   479 LTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	127/485 (26%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	147/549 (27%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	93/302 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910