DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	551	Identity:	150/551 - (27%)
Similarity:	250/551 - (45%)	Gaps:	83/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LTLLIYG--AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT-- 75
            |.|.::|  |..|..|.:|| :..||.:..:.|.:.|.::||.|.|:.. |.:|..|..:..|
Mouse    17 LLLCVFGPSASHAGRLLVFP-MDGSHWLSMLGVIQQLQQKGHEVVVIAP-EASIHIKEGSFYTLR 79

  Fly    76 ---VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADV-LKDQRVKELYLN-- 134
               ||..||.:......:|    .|:.|:           ||.|.::..: :|.:|...:.|.
Mouse    80 KFPVPFQKENVTATLVELG----RTAFNQ-----------DSFLLRVVKIYMKVKRDSSMLLAGC 129

  Fly   135 -------------KDNHFDLVISG------------------YFMNDYQLGFARKVNAPVVVLAP 168
                         :::|||.:::.                  ||:|........:.....|.|:.
Mouse   130 SHLLHNAEFMASLEESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSY 194

  Fly   169 SPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMP 233
            .|.|...||      |:      |.|.||:.:.:.::......|.:.........||...:.|:
Mouse   195 VPKSLSFNS------DR------MNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEVTV- 246

  Fly   234 EYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAIL 296
              .|:|...|:....|....:.| ||.:|..:.||||....| .||.:..|.:: ||:  ||.::
Mouse   247 --QDLLSPASIWLMRSDFVKDYP-RPIMPNMVFIGGINCLQK-KPLSQEFEAYV-NASGEHGIVV 306

  Fly   297 LSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSV 361
            .||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|.||..
Mouse   307 FSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKT 368

  Fly   362 KLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEIL 426
            :.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|:..::
Mouse   369 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 433

  Fly   427 SNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALI 490
            :|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||:...:
Mouse   434 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFL 497

  Fly   491 GAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            .||.:.::.::.|.....||:......:|||
Mouse   498 LAIVLTVVFIVFKCCAYGCRKCFGGKGRVKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/471 (26%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	142/525 (27%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	142/534 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840