DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	535	Identity:	152/535 - (28%)
Similarity:	253/535 - (47%)	Gaps:	57/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTIT---HKNINLV---- 74
            ||..|...|..|.:.| :..||.....:|.:.|..:||.|.||.   |.::   .|.:|.|
Mouse    17 LLASGLAQAGRLLVVP-MDGSHWFTMQTVVEKLLHKGHEVVVVV---PEVSWQLTKPLNFVVKTY 77

  Fly    75 TVPMTKEEIKQRSET-IGAKQKNTSSNRFISILN--MSGQMDSMLRKMADVLKDQRVKELYLNKD 136
            .|..|:|::.:..:. |.|:.|:......:.:|:  ..|..:.:......:..|:::.| || |.
Mouse    78 AVSHTQEDLNREFKIFIDAQWKSQQEGGILPLLDSPAKGFFELLFSHCRSLFNDKKLVE-YL-KQ 140

  Fly   137 NHFDLVISGYFMNDYQ---LGFARKVNAPVVVLA--------------PSPPSQMLNSLIGNPHD 184
            ..||.|    |::.:.   |..|:..:.|.||.:              |||||.:       |..
Mouse   141 TSFDAV----FLDPFDVCGLTVAKYFSLPSVVFSRGIFCHYLEDAAQCPSPPSYI-------PRM 194

  Fly   185 KVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCS 249
            .::....|||.:|..:.::.:....|..:..:......:|:.....||   ||:....|:....:
Mouse   195 LLKFTDTMTFKERTRNLLAYMGERAFCHKFFKSAADIASEVLQTPVTM---TDLFSPVSIWLLRT 256

  Fly   250 HAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADT 312
            ....|.| ||.:|..|.||||.. .:..||.|..|.:: ||:  ||.::.||||.|  |.|....
Mouse   257 DFVLEFP-RPVMPNVIYIGGINC-HQGKPLSKEFEAYV-NASGEHGIVVFSLGSMV--SEIPEKK 316

  Fly   313 VKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQ 377
            ..:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|.||..:.||.|:|..||.|..
Mouse   317 AMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGI 380

  Fly   378 YHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLY 442
            .:|.||:.:|:||||..||..|...|.|:||::|.:..:....|:..:::|..|.:.:::.|||:
Mouse   381 CNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLH 445

  Fly   443 RDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQ 506
            :|||....:..:||.|||:||.||.||: |..| :.:...::||:...:.||.:.::.::.|...
Mouse   446 KDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCA 509

  Fly   507 ITCRRLRTKLNKVKK 521
            ..||:......:|||
Mouse   510 YGCRKCFGGKGRVKK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	126/459 (27%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	145/522 (28%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	94/287 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840