DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2b10

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001178605.1	Gene:	Ugt2b10 / 305264	RGDID:	1309989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	141/573 - (24%)
Similarity:	248/573 - (43%)	Gaps:	96/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VGRTKSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTI 66
            |.||.|..:::|.|:.......|..:| ::| :..||.:....:...|.::||.   ||||.|
  Rat     3 VKRTASLLLLLLQLSDFFGSGTGGKVL-VWP-MEFSHWLNLRVILDELLKKGHE---VTVLRP-- 60

  Fly    67 THKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRF------ISILNMSGQMDSMLRKMADVLKD 125
                                |.::..:..|||:..|      .|:..:.......|||....|..
  Rat    61 --------------------SASLSYEVDNTSAIEFETYPTSYSLTEVDEFFWESLRKYIYELPK 105

  Fly   126 QR----------------------VKELYLNKD-------NHFDLVISGYFMNDYQLGFARKVNA 161
            |.                      .|::..||:       :.||::::..|:....| .|..:..
  Rat   106 QSFWGYFLMFQELVWVDSDYFESLCKDVVFNKELMTKLQNSGFDVILADPFIPCGDL-LAEILKI 169

  Fly   162 PVVVL---------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFL 211
            |:|..               .|.|||.:       |....|....|||.:|:...|..|.:..:.
  Rat   170 PLVYSLRFFPGSTYEKYSGGLPMPPSYV-------PIAMSELSDRMTFVERMKHMIYVLCFDFWF 227

  Fly   212 RQIDQRN-RQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDK 275
            :..:::. .:.|.|:.|...|:.|   .:....:....::...|.| .|.:|....:||:..: .
  Rat   228 QAFNEKKWNELYTEVLGRPTTLSE---TMAKADIWLIRTYWDLEFP-HPVLPNFDFVGGLHCR-P 287

  Fly   276 PDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPG 339
            ..||||.:|.|: .:..||.::.||||.|  .::..:....|.:.|:.:.|:|:|:::.......
  Rat   288 AKPLPKEIEDFVQSSGEHGVVVFSLGSMV--GNLTEERANVIAAGLAQIPQKVLWRFEGKKPETL 350

  Fly   340 KSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGF 404
            .|:..|| :|:||:|:|.||..:.||.|.|..||.||.|||.|::.:|:||||..|...:...|.
  Rat   351 GSNTRLY-KWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKTKGA 414

  Fly   405 GLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHL 469
            .:.|..||:.......|:..|.::|.|.:..::.|.::.|:|....:..:||.|:|:||.||.||
  Rat   415 AVRLDFLTMSSTDLFTALKTITNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHL 479

  Fly   470 QSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            :.....:.::..::||:...:.|..:.::.:|||.....|::. ||..:.||:
  Rat   480 RVAAHDLSWVQYHSLDVIGFLLACVVTVMFILKKCCLFCCQKF-TKAGRKKKR 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	113/482 (23%)
Ugt2b10	NP_001178605.1	UDPGT	26..529	CDD:278624	132/546 (24%)
Ugt2b10	NP_001178605.1	egt	35..510	CDD:223071	124/515 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930