DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	156/568 - (27%)
Similarity:	266/568 - (46%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVT-----VLEPTIT 67
            :.:::|.::..:..|:...:| ::| :..||.:...::...|.::||.|||:.     ||:|. .
  Rat     7 FALLLLQISFCLRSAKCGKVL-VWP-MEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPK-K 68

  Fly    68 HKNINLVTVP--MTKEEI-KQRSETIGA----KQKNTSSNRFISILNMSGQMDSMLRKMAD---- 121
            ..::...|.|  ::|:|: |...:.:.|    .|::|       .|:.|..:.:|:.:.:|
  Rat    69 SPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDT-------CLSFSPLLQNMMDEFSDYYLS 126

  Fly   122 VLKDQRVKELYLNK--DNHFDLVISGYFMNDYQLGFARKVNAPVV----VLAPSPPSQMLNSLIG 180
            |.||....:..:.|  ::.||:::|.                ||.    ::|.......|.||..
  Rat   127 VCKDAVSNKQLMAKLQESKFDVLLSD----------------PVAACGELIAEVLHIPFLYSLRA 175

  Fly   181 NPHDKVEKEKG-------------------MTFGQRLDSYISSLLYGIFLRQIDQRN-RQYYNEI 225
            :|..|:||..|                   |||..|:.:.|..|.:..:....:.:| ..:|.||
  Rat   176 SPGHKIEKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFDFWFHMFNAKNWDPFYTEI 240

  Fly   226 FGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GN 289
            .|...|:.|   .:....:....|:...|.| .|::|....|||:|.| ...||||::|.|: .:
  Rat   241 LGRPTTLAE---TMGKAEMWLIRSYWDLEFP-HPTLPNVDYIGGLQCK-PAKPLPKDIEDFVQSS 300

  Fly   290 ATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGK-SDNILYSRWLPQD 353
            ..||.::.||||.|  |.:..:....:...|:.:.|:|:||:|  .|.|.. ..|....:||||:
  Rat   301 GEHGVVVFSLGSMV--SSMTEEKANAVAWALAQIPQKVLWKFD--GKIPATLGPNTRVYKWLPQN 361

  Fly   354 DILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPF 418
            |:|.||..|.|:.|.|..|:.||.|||.||:.:|:||:|..|...||..|..:||::.|:.:...
  Rat   362 DLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDL 426

  Fly   419 RAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAAN 482
            ..|:.|:::||.|.:..:..|:::.|:|....:..|||.|||:||..|.||: ||.| :.:...:
  Rat   427 FNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLR-PLGHNLPWYQYH 490

  Fly   483 NLDIYALIGAISIGLLLMLKKVV---QITC-----RRLRTKLNKVKKQ 522
            :||:        ||.||....|:   .:.|     |....|..|:|.:
  Rat   491 SLDV--------IGFLLACLAVIAALAVKCFLFIYRFFAKKQKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	129/474 (27%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	152/546 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910