DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	146/554 - (26%)
Similarity:	267/554 - (48%)	Gaps:	74/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLALTLLIYGAQGA--NILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVT-----VLEPTITH 68
            :.|.:.|:.|...||  .:| ::|: ..||.|....:...||::||.|||:.     ::|||...
  Rat     8 VFLLIQLICYFRPGACGKVL-VWPT-EYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKES 70

  Fly    69 K-NINLVTVPMTKEEIKQRSETIGAKQKNTSSNRF--ISILNMSGQMDSMLRKMADVLKDQRVKE 130
            . |..:.:||::|.::    |...||..:..:..|  :||.....:|..:..:.:||: :...|.
  Rat    71 SINFEIYSVPLSKSDL----EYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVV-ENLCKA 130

  Fly   131 LYLNKD-------NHFDLVIS------GYFMND-------YQLGF-----ARKVNAPVVVLAPSP 170
            |..||.       :.||::::      |..:.:       |.|.|     ..|.:..:    |.|
  Rat   131 LIWNKSLMKKLQGSQFDVILADAVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGL----PLP 191

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRN-RQYYNEIFGDDPTMPE 234
            ||.:       |....|....|||.:|:.:.:..|.:..:.:...::: .|:|:::.|...|:
  Rat   192 PSYV-------PVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLGRPTTL-- 247

  Fly   235 YTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLS 298
             |:::....:....:....|.| .|.:|....:||:..| ...|||:.:|:|: .:..||.::.|
  Rat   248 -TEMMGKADIWLIRTFWDLEFP-HPFLPNFDFVGGLHCK-PAKPLPREMEEFVQSSGEHGVVVFS 309

  Fly   299 LGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYS-----RWLPQDDILAH 358
            |||.|:  ::..:....:.|.|:.:.|:|:|::|      ||..:.|.|     :|:||:|:|.|
  Rat   310 LGSMVK--NLTEEKANVVASALAQIPQKVVWRFD------GKKPDTLGSNTRLYKWIPQNDLLGH 366

  Fly   359 PSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVL 423
            |..|.|:.|.|..||.||.|||.|::.:|:|.|||.|.:.||..|..:.:....|.......|:.
  Rat   367 PKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALK 431

  Fly   424 EILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYA 488
            .::::|.|.:..::.|.::.|:|....:..:||.|||:||.||.||:|.|..:.:...::||:..
  Rat   432 IVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIG 496

  Fly   489 LIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            .:....:|::.::.|.....||: ...:.|.||:
  Rat   497 FLLLCVVGVVFIITKFCLFCCRK-TANMGKKKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	120/472 (25%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	139/534 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910