DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	141/520 - (27%)
Similarity:	253/520 - (48%)	Gaps:	92/520 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIISMSVAKILAEQGHNVTVVT-----VLEP-TITHKNINLVTVPMTKEEIKQRSETIGAKQK 95
            ||.:....:...|.::||.|||:.     .|:| ..:.....:.:..::|:|::
  Rat    34 SHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQ----------- 87

  Fly    96 NTSSNRFISILNM-------------SGQMDSMLRKMA----DVLKDQRVKELYLNK--DNHFDL 141
                |.||.:|::             |..:.:::.:.:    .:.||....:..:.|  ::.||:
  Rat    88 ----NHFIKLLDVWTYELPRDTCLSYSPILQNLVYEFSYFYLSICKDAVSNKQLMTKLQESKFDV 148

  Fly   142 VIS------GYFMND-------YQLGFA--RKVNAPV--VVLAPSPPSQMLNSLIGNPHDKVEKE 189
            :.:      |..:.:       |.|.|:  .|:...:  .:|.||....:|:.|.|.
  Rat   149 LFADPVASCGDLIAELLHIPFLYSLSFSPGHKLEKSIGKFILPPSYVPVILSGLAGK-------- 205

  Fly   190 KGMTFGQRLDSYISSLLYGIFLRQIDQRNRQ---YYNEIFGDDPTMPEYTDILRNTSLVFFCSHA 251
              |||..|:.:.|..|.:..:...:  |:::   :|:||.|...|:.|   .:....:....|:.
  Rat   206 --MTFIDRVKNMICMLYFDFWFEIL--RHKEWDTFYSEILGRPTTVDE---TMSKVEIWLIRSYW 263

  Fly   252 ASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVKK 315
            ..:.| .|::|....|||:..| ...||||::|:|: .:..||.::.||||.|  |::..:....
  Rat   264 DLKFP-HPTLPNVDYIGGLHCK-PAKPLPKDMEEFVQSSGEHGVVVFSLGSMV--SNMTEEKANA 324

  Fly   316 IFSVLSNLKQRVIWKWDDLDKTPGK-SDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYH 379
            |...|:.:.|:|:||:|  .|||.. ..|....:||||:|||.||..|.|:.|.|..|:.||.||
  Rat   325 IAWALAQIPQKVLWKFD--GKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYH 387

  Fly   380 GKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRD 444
            |.||:.:|:|||||.|...||..|..::|::.|:.:..|.:|:.|::.||.|.:.|:..|:::.|
  Rat   388 GIPMIGIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHD 452

  Fly   445 RPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDI-------YALIGAISIGLLLML 501
            :|....:..:||.|:::||.||.||: ||.| :.:...::||:       :|:|.|:::..||.:
  Rat   453 QPMKPLDRAVFWIEFIMRHKGAKHLR-PLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLFM 516

Fly 502 501
Rat 517 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/465 (26%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	141/520 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910