DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	150/556 - (26%)
Similarity:	259/556 - (46%)	Gaps:	65/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVGRTKSYFVIVLALTLLIYG--AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLE 63
            :|.|:....:::..|.|.:.|  |..|..|.:.| :..||.:..:.|.:.|.::||.|.|:.. |
  Rat     3 VVCRSSCSLLLLPCLLLCVLGPSASHAGKLLVIP-IDGSHWLSMLGVIQQLQQKGHEVVVIAP-E 65

  Fly    64 PTITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISI-LNMSGQMDSMLRKMADVLKDQR 127
            .:|..|..:..|  |.|..:..::|.:.|        .|:.: .::..|...:||.:....|.:|
  Rat    66 ASIHIKEGSFYT--MRKYPVPFQNENVTA--------AFVELGRSVFDQDPFLLRVVKTYNKVKR 120

  Fly   128 VKELYLN---------------KDNHFDLVISGYFMNDYQLGFARKVNAPVVVL----------- 166
            ...:.|:               :.:|||.:::..|:....: .|:.::.|.|..
  Rat   121 DSSMLLSGCSHLLHNAEFMASLEQSHFDALLTDPFLPCGSI-VAQYLSLPAVYFLNALPCSLDLE 184

  Fly   167 ---APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGD 228
               .|:|.|.:..||..|. |:      |.|.||:.:.|.:|......|.:.........||...
  Rat   185 ATQCPAPLSYVPKSLSSNT-DR------MNFLQRVKNMIIALTENFLCRVVYSPYGSLATEILQK 242

  Fly   229 DPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT-- 291
            :.|:   .|:|...|:....:....:.| ||.:|..:.||||....| ..|.:..|.:: ||:
  Rat   243 EVTV---KDLLSPASIWLMRNDFVKDYP-RPIMPNMVFIGGINCLQK-KALSQEFEAYV-NASGE 301

  Fly   292 HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDIL 356
            ||.::.||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|
  Rat   302 HGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLL 363

  Fly   357 AHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAA 421
            .||..:.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|
  Rat   364 GHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 428

  Fly   422 VLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLD 485
            :..:::|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||
  Rat   429 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLD 492

  Fly   486 IYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :...:.||.:.::.::.|.....||:......:|||
  Rat   493 VIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	121/462 (26%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	140/525 (27%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	85/252 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910