DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	538	Identity:	152/538 - (28%)
Similarity:	265/538 - (49%)	Gaps:	55/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLE-----PT 65
            |||....:.|...:..|:.|.|:.:.|.:..|||.|..::|..|.|:||: ||:.:.|     |:
Mouse     2 KSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHH-TVLLLSEGRDIAPS 65

  Fly    66 ITHKNINLVTVP-----MTKEEIKQRSETIGAKQKNTSSNR-----FISIL-NMSGQMDSMLRKM 119
               .:.:|...|     .|.:...|      :|.:|..|.|     .:.|| :.:...|.|:...
Mouse    66 ---NHYSLQRYPGIFNSTTSDAFLQ------SKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQ 121

  Fly   120 ADV--LKDQRVKELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQM--LNSLIG 180
            |.:  ||.::...|.::.::....||:......|.: |:..:..|..|.||:|.:.:  .|||:.
Mouse   122 ALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAV-FSTGLWYPAEVGAPAPLAYVPEFNSLLT 185

  Fly   181 NPHDKVEKEK--GMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTS 243
            :..:.:|:.|  |:....|:.  :|.|:...:     :|..|.||.:    |....| |::..:|
Mouse   186 DRMNFLERMKNTGVYLISRIG--VSFLVLPKY-----ERIMQKYNLL----PAKSMY-DLVHGSS 238

  Fly   244 LVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNA-THGAILLSLGSNVQGSH 307
            |...|:..|.|.| ||::|..:.:|||..| ...|||::|::::..| .||.:|:|.|:.|:  :
Mouse   239 LWMLCTDVALEFP-RPTLPNVVYVGGILTK-PASPLPEDLQRWVSGAQEHGFVLVSFGAGVK--Y 299

  Fly   308 IKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGG 372
            :..|...|:...|..|.|:|||::.. .|.....:|.....||||:|:|.|.:::.|::|.|...
Mouse   300 LSEDIANKLAGALGRLPQKVIWRFSG-TKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNS 363

  Fly   373 ISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVK 437
            |.|..|||.|::.:|:|||.......:...|.|:.|...|:.|.....|::::::||.|.||..|
Mouse   364 IFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQK 428

  Fly   438 FSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDI--YALIGAISIGLLLM 500
            .|.:::|:|........:|.:|::||.||.||:|.:..:.|.....|||  ..|:||:.  |..:
Mouse   429 LSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVL--LYFI 491

  Fly   501 LKKVVQITCRRLRTKLNK 518
            |..|.:...|::::..:|
Mouse   492 LSYVTKFIYRKIKSLWSK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	126/453 (28%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	145/510 (28%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840