DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	551	Identity:	153/551 - (27%)
Similarity:	257/551 - (46%)	Gaps:	80/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVTV 76
            :|.|...:..|:||.:|.|  .:..|..:....|.:.|..:||. |||...|.|:..|..:..|:
Mouse    15 LLLLLCALPWAEGAKVLVL--PMEGSQWLSMRDVVRELHARGHQ-TVVLASEVTVHIKGEDFFTL 76

  Fly    77 -----PMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKELYLNK- 135
                 |.||||.:|  |.:...:|...:..|:...   .:..:.:|...|:..:..:..|: ||
Mouse    77 KTYAFPYTKEEYQQ--EILSDIEKTFKTQHFVKAF---FETTASIRNFFDLYSNSCIALLH-NKM 135

  Fly   136 ------DNHFDLVISGYFMNDYQLG--FARKVNAPVVVL--------------APSPPSQMLNSL 178
                  .:.||::::...   :..|  .|:.:..|.|.:              .|:|.|.:.|.|
Mouse   136 LIQQLNSSFFDVILTDPI---FPCGAVLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLL 197

  Fly   179 IGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDIL-RNT 242
                   ......|.|.||    :.::||.:.|:.|.:.:...|..:         .:::| |..
Mouse   198 -------TRLSDHMDFLQR----VQNMLYYLVLKYICRLSITPYESL---------ASELLQREV 242

  Fly   243 SLVFFCSHAA---------SEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAIL 296
            |||...|||:         .:.| ||.:|..:.||||....| .||.:..|.:: ||:  ||.::
Mouse   243 SLVEVLSHASVWLFRGDFVLDYP-RPIMPNMVFIGGINCVTK-KPLSQEFEAYV-NASGEHGIVV 304

  Fly   297 LSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSV 361
            .||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|.||..
Mouse   305 FSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKT 366

  Fly   362 KLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEIL 426
            :.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|:..::
Mouse   367 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 431

  Fly   427 SNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALI 490
            :|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||:...:
Mouse   432 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFL 495

  Fly   491 GAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            .||.:.::.::.|.....||:......:|||
Mouse   496 LAIVLTVVFIVFKCCAYGCRKCFGGKGRVKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	126/470 (27%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	146/534 (27%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	31/141 (22%)
		egt	<261..505	CDD:223071	86/250 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840