DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-3

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_506203.2	Gene:	ugt-3 / 191174	WormBaseID:	WBGene00013903	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	144/571 - (25%)
Similarity:	250/571 - (43%)	Gaps:	101/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTI----THK 69
            ::::||...:.:   |.|.|.:.|....||:.....:|.|||:.|||   ||:.:|.|    .||
Worm     3 YLLLLAFFPVAF---GFNYLIISPVFGYSHMKFMGRIADILADAGHN---VTLFQPIIYDYYAHK 61

  Fly    70 ------NINLVTVPMTKEEIKQRSETIGAK-------QKNTSSNRFISILNMSGQMDSMLRKMAD 121
                  ||.::...:.:||....||....|       .||..|:..|:...:..:.:.:.|||
Worm    62 KIVKNPNIEVINYEVDEEEKAAASEASVFKFFWKAKGSKNPISSAKITSEKLYKEFEHICRKM-- 124

  Fly   122 VLKDQRVKELYLNK--DNH----FDLVISGYFMNDYQLGFARKVNAPV-------------VVLA 167
             |.|:.:....|:|  |:|    ||  ..|.::.|:     .|:.:|:             .|..
Worm   125 -LLDKELHRWILSKNFDSHISEAFD--FCGLYLGDF-----LKLKSPIPLYSGVRCGAASYAVGE 181

  Fly   168 PSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSY--ISSLL--------YGI-FLRQIDQRNRQY 221
            |.|    ||.|         ..:|..:|::..:.  :|.:|        :|| |.:|.||..|
Worm   182 PIP----LNYL---------PTEGSNYGKKSSAIDRLSDMLGLTGYHFQFGILFDKQYDQAYR-- 231

  Fly   222 YNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPI----RPSVPAAIEIGGIQIKD-KPDPLPK 281
               :.|.:  :..:.:||::::  ||.:::   .|.    .|::...|:|||..|:. |...|.:
Worm   232 ---LTGGN--VRTWQEILQSST--FFLTNS---NPYLSFSTPTISKVIQIGGFTIESFKTTTLDE 286

  Fly   282 NLEKFLGNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRV-IWKWDDLDKTPGK--SDN 343
            ...|.| :..:..||:|.|:.:|.|.:..|....:......:.... |||:::.|||...  |:|
Worm   287 EFNKIL-SLRNNTILVSFGTVIQSSDMPDDFKTGLIEAFRRMPDATFIWKYEEDDKTLKNKLSEN 350

  Fly   344 ILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTL 408
            ::.|:|:||..:||...:.||:.|.|.|...|..|.|...:.:|||.||..||..:.:.|..:..
Worm   351 VVLSKWIPQPALLADSRLDLFVTHGGLGSTMEVGYAGVSSIMVPVFSDQGVNAEMLARHGGAIVY 415

  Fly   409 SLLTL-EEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSP 472
            ....| :.:.....:..||:|..|.:...:.|.:..::|...::.|:...|:..|.....:|:..
Worm   416 DKFDLVDSKKLMETIQMILNNSDYRKNSKRLSDILHNQPMDPKQVLLNHCEFAARFAQVDNLEPY 480

  Fly   473 LVHMDFIAANNLDIYAL-IGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            ....:||....||..|| :..||:..|:|. |::......:..|| |:||:
Worm   481 ANKYNFIEFYCLDSLALVVCTISVVALVMF-KILSFVVNSVIEKL-KLKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/486 (25%)
ugt-3	NP_506203.2	egt	1..457	CDD:223071	124/495 (25%)
ugt-3	NP_506203.2	UDPGT	27..525	CDD:278624	135/538 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960