DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A1 and ugt-59

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_501911.1	Gene:	ugt-59 / 187799	WormBaseID:	WBGene00011238	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	132/540 - (24%)
Similarity:	224/540 - (41%)	Gaps:	100/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKSYFVIVLALTLL--IYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVV------TV 61
            |:..|.|:|..|::  .|   ..|||...|:||.||:..:..:|::||..||.|||:      .:
Worm     2 TQFLFKILLVCTIINEFY---TLNILFYVPTLSHSHISFNTKLAQLLATSGHQVTVLLAQVDDAL 63

  Fly    62 LEPTITHKNINLVTVPMTKEEIKQ-RSETIGAKQKNTSSNR--FISILNMSGQMDSMLRKMADVL 123
            |....|...:....|.:.:..::| .....|..:.::..|.  |..:|.:||...:..:.||
Worm    64 LIENATDFAVLRKKVGVPRGHLRQVLWSNPGPYEDSSPLNPRIFYKLLKVSGTFVTACQNMA--- 125

  Fly   124 KDQRVKELYLN--KDNHFDLVI--------SGYFMNDYQLGFARKV--NAPVV------VLAPSP 170
                ...|:|:  :...||:.:        .|.|.:   :|....|  :|..:      .|....
Worm   126 ----FDHLFLSSLQQQKFDVGLVEQYDSCGFGIFKS---IGIENTVWLSATAIYRPQAEALGVHL 183

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYI----SSLLYGIFLRQIDQRNRQYYNEIFGDDPT 231
            |...:..|..:..||      |:|.|::.:.:    :|.:..:|::....|       |||.:..
Worm   184 PYSYVPELFAHFSDK------MSFFQKVINILIGQATSFVLDVFVQGFQSR-------IFGFEQG 235

  Fly   232 M----PEYTDILRNTSLVFF-----CSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL 287
            :    .|.:.:|.| |:.||     .||..|            .||||.:..:...|....:...
Worm   236 LGAISQETSSVLIN-SVPFFDYSMPVSHQFS------------NIGGITVDKRDKKLDPYWQSIA 287

  Fly   288 GNATHGAILLSLGSNVQGSHIKADTVKKI----FSVLSNLKQRVIWKWD-DLDKTPGKSDNILYS 347
            .:|.:|.:|:|.| .:..:....:::::|    |:..|::  ..|.|:: ..:.|....||::.:
Worm   288 DSAENGFVLVSFG-GIARTVDMTESMQRIFYDSFARFSHI--TFIVKYETSSNSTISVPDNVILT 349

  Fly   348 RWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLT 412
            .|:||..::||.:.|..|.|.|...|.|...|.|||:.:|:|.|...|:......|..:.|..:.
Worm   350 PWIPQLPLMAHKNYKTIITHGGWSSILETTMHSKPMILMPLFADHAKNSKVAESKGVAVLLDKMR 414

  Fly   413 LEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHG-------AAHLQ 470
            |.......|:..||:||||:|...|||.::.|.|. ..|.||.|.   ||...       |.||:
Worm   415 LSRRRVVHAIYTILTNPKYTQNCEKFSRMFSDTPI-PHEELIEWR---IRQAAKPSRKAFAKHLR 475

  Fly   471 SPLVHMDFIAANNLDIYALI 490
            .......::....|.|.|:|
Worm   476 PKEPDFSYLKLGFLIIPAMI 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	116/475 (24%)
ugt-59	NP_501911.1	UDPGT	33..490	CDD:278624	116/499 (23%)
ugt-59	NP_501911.1	Glycosyltransferase_GTB_type	<247..492	CDD:299143	71/264 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010