DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-38

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	130/539 - (24%)
Similarity:	217/539 - (40%)	Gaps:	71/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIY-GAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINL 73
            :::|||...:| .....|.|...|..:.||.....::|..|.:.||||...|   |.|..|..|.
Worm     1 MLLLALLFTLYANVSSFNFLVFCPLFAHSHSKFFATIADSLTDAGHNVAFFT---PIIVEKYRNF 62

  Fly    74 VTVPMTKEEI-KQRSETIGAKQKNTSSNRFI----------SILNMSGQMDSMLRKMADVLKDQR 127
            .....||:.: .:.|:.:....:..|:..|:          .|:.:......|..:...|:|| .
Worm    63 NYTKSTKDVVYMEPSKKLKEYGRQMSTGDFVRYWTEDSTATEIITVVRIFQKMYNEQGTVMKD-N 126

  Fly   128 VKELYLNKDNHFDLVI------SGYFMNDY--------QLGFARKVNAPVVVLAPSPPSQMLNSL 178
            ::.|...|...||::|      |.|.:.||        .|..|......|.:..|..||.:.:.|
Worm   127 IEILNDLKKRKFDVIIFEAFIFSAYPLMDYLEIPTFIPSLSVAHDTALAVEIGEPVMPSVVSDCL 191

  Fly   179 IGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPT----MPEYT--- 236
              :|           ||.:|.  |:...:..|:       ..|::.:.| .||    .|.|.
Worm   192 --SP-----------FGDKLS--ITERAFNAFM-------VPYFDFMIG-YPTHRSFKPPYNPID 233

  Fly   237 --DILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKD---KPDPLPKNLEKFLGNATHGAIL 296
              .|:...|.||..|:...:.| ||::...|:||||.:..   :...|.:...:.| ......:|
Worm   234 IRSIVPEASFVFLNSNPFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDETWSEIL-KLREKTML 296

  Fly   297 LSLGSNVQGSHIKADTVKKIFSVLSNLKQ-RVIWKWDD--LDKTPGKSDNILYSRWLPQDDILAH 358
            :|.||.:....:.......:.:.:...|. ..|||::|  .|:.....:||.:::|:||..:||.
Worm   297 VSFGSMLYSKDMPFKNKIALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLAD 361

  Fly   359 PSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTL-EEEPFRAAV 422
            ..:..|:.|||.|.|:|..|.|||.:..|...||..|...:|:....:.||...| :.|....|.
Worm   362 SRLSAFLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRHNGSIELSKYDLGKSEKIIEAF 426

  Fly   423 LEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIY 487
            ..||.:..|::...|.:....::|...:|.::...||..|......|......|.|:....||:.
Worm   427 QAILFDSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRLPSLDPYSRKMSFVEYFLLDVA 491

  Fly   488 ALIGAISIGLLLMLKKVVQ 506
            |:...|...::.::.|:||
Worm   492 AICVFILTFVVFVVTKLVQ 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	113/471 (24%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	126/528 (24%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	123/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910