DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-40

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	133/549 - (24%)
Similarity:	226/549 - (41%)	Gaps:	70/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINL 73
            |.:.|...|||......|||...|....||......:|.||.|.|||   ||:..|||..:..|.
Worm     4 FSLYLYYLLLISSTTSYNILVFCPLFGHSHSTFFGRLADILTEAGHN---VTLFSPTIIDEFRNY 65

  Fly    74 VTVPMTKE--------EIKQRSETIGAKQK--NTSSNRFISILNMSGQMDSMLRKMADVLKDQRV 128
            ....:||:        |:|...:.|...::  |...:.| .|...:....|:.|:..:||.: .:
Worm    66 SYTKLTKDVAYLDPSPELKAIGDLIAGNKRWWNQEFSVF-EIPQTTRFFKSITREQNNVLAN-NL 128

  Fly   129 KELYLNKDNHFDLVI-SGYF-----MNDY----QLGFARKVNAPVVVLAPSPPSQMLNSLIGNPH 183
            ..|...|...|||:: ...|     :.:|    ....|:.:....:.|.....:.|.:.:   |:
Worm   129 ALLDGLKQKKFDLILFESVFTCALPLMEYLEIKSFAVAQSIAYEPITLGALGDTVMTSHI---PN 190

  Fly   184 DKVEKEKGMTFGQR-LDSYISSLL--YGIFLRQIDQRNRQYYNEIFGDDPTMPE---YT-DILRN 241
            ...:....|:..:| |::.|.::|  ||:        ..:||...     |.||   || :.|..
Worm   191 LMAQSSDKMSLCERMLNTLIQAMLNVYGM--------TPEYYQSY-----TNPEKKIYTLEKLSE 242

  Fly   242 TSLVFFCSHAASEGPIRPSVPAAIEIGGIQIK----DKPDPLPKNLEKFLGNATHGAILLSLGSN 302
            .|.:|..|:...:.| |.::...|:||||.:.    .....|.:..::.| |.....:|:|.||.
Worm   243 ASFIFMNSNPFLDFP-RATITKNIQIGGISVNLDTLKSSGKLTEEWDQIL-NLREKTLLVSFGSV 305

  Fly   303 VQGSHIK-------ADTVKKIFSVLSNLKQRVIWKW--DDLDKTPGKSDNILYSRWLPQDDILAH 358
            :....:.       .:.:|::..|      ..|||:  ||..:......||.:|:|:||.::||.
Worm   306 ILSQDMPFAYKVGLTNAMKQLNDV------TFIWKYEGDDKKEFANGIKNIHFSKWVPQRELLAD 364

  Fly   359 PSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRA-AV 422
            |.:..|:.|.|.|.::|..|.|||.:..|:.|||..||..:.:....:..|...|..|...| |.
Worm   365 PRLSAFMTHGGLGSVNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEFSKYDLHNEKVVANAF 429

  Fly   423 LEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIY 487
            .:||.:..|:....:.|...:.:|...:|..:...|:..|......|......|.||....:||.
Worm   430 RKILYDESYTLSAKRLSEHLQFQPVKPKELFLKHVEFAARFGKLPSLDPYSRQMGFIQYFLIDIA 494

  Fly   488 ALIGAISIGLLLMLKKVVQITCRRLRTKL 516
            .::..:.:.::.:|..|::.....|:.|:
Worm   495 FIVLTVVLTIVSVLYFVLKFVASCLKAKI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	116/471 (25%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	112/453 (25%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	66/263 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910