DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-36

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_504820.2	Gene:	ugt-36 / 184266	WormBaseID:	WBGene00017315	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	137/567 - (24%)
Similarity:	232/567 - (40%)	Gaps:	94/567 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKN 70
            |..|.:..||.     :...|.|...|....||......:|..|...|||||..|   |||..|.
Worm     9 KLLFCLFFALC-----SDSYNFLVFCPLFGHSHTTFFAKIADTLTYAGHNVTFFT---PTIVRKF 65

  Fly    71 INLVTVPMTKEEIK----QRSETIGA--KQKNTS-----SNRFISILNMSGQMDSMLRKMADVLK 124
            ..:..|......::    .|...:|:  ::|:.|     .:....:|.|....::|..:.|.|:.
Worm    66 SKIQYVKSITHVLQLDPSDRLVKLGSMFEEKDVSKFWYRDSSLSEMLPMIDTFNNMFVEQAAVIS 130

  Fly   125 DQRVKELYL---NKDNHFDLVISGYFMN------DY----------QLGF----ARKVNAPVVV- 165
                :.|::   .|:.:||::|..:|:.      ||          .|.|    .:.:..|:::
Worm   131 ----RNLHVLDDLKEMNFDVMIFEHFVEPAYLVLDYLEIQKFIPATSLAFDYNMVKSIGEPLMLS 191

  Fly   166 LAPSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDP 230
            ..|.|.|              |....|:..|||.:.|:.|::...:.:  .:.|.|
Worm   192 TVPLPTS--------------EYSDRMSLPQRLINAINPLIFDNLIPK--NKYRSY--------- 231

  Fly   231 TMPEYTDILRNT-SLVFFCSHA-ASEGPI----RPSVPAAIEIGGIQI---KDKPDPLPKNLEKF 286
             .|.|..|  || |:..|||.. .:..|.    |.::...:::|||.:   |.|...:....:..
Worm   232 -RPPYAPI--NTKSIEPFCSAVFTNSNPYIDYPRATLEKNVQVGGISVDIDKLKSQKVSNEWDAV 293

  Fly   287 LGNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQ-RVIWKWDDLDKT-PGKSDNILYSRW 349
            | |.....:|:|.||.:....:..:....|.:||..... ..|||::..|.: ...::||.:|.|
Worm   294 L-NLRPKTVLVSFGSIMLSKDMPINNKITIATVLGKFPDVTFIWKYETNDTSFANGTENIHFSNW 357

  Fly   350 LPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLE 414
            :||..:||.|.:..|..|||.|.::|..|.|||.:..|:|.||..||..:.:....:.:|...|.
Worm   358 VPQTALLADPRLSAFFTHAGLGSVNEVSYLGKPTIMCPIFADQMRNAKMLARHNGSIEISKYDLS 422

  Fly   415 E-EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH--- 475
            . :....|:.:||.:..|.....|.:....::|...:|.|:...|:..:.   .||.|...|
Worm   423 NGDKIEEALSKILFDESYKTAAEKLAHQLANQPVKPKELLVRHAEFAAQF---GHLPSLDPHSRQ 484

  Fly   476 MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            |.||....:|:.|:|.:..|..|.:|.|:.::...:|...|:.||::
Worm   485 MSFIQYFLIDLTAIILSTVILFLFVLFKLGKLMYSKLPFNLSLVKQK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	114/477 (24%)
ugt-36	NP_504820.2	Glycosyltransferase_GTB_type	6..507	CDD:299143	130/541 (24%)
ugt-36	NP_504820.2	YjiC	25..455	CDD:224732	110/465 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910