DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A1 and ugt-21

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001293944.1	Gene:	ugt-21 / 183141	WormBaseID:	WBGene00007885	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	131/546 - (23%)
Similarity:	233/546 - (42%)	Gaps:	62/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSL-SPSHLIISMSVAKILAEQGHNVTVV-----------TVLEP 64
            :..||.:|.......|| |:.:| ..||:.:..:.|.||.:.|:||||:           |.|:.
Worm     7 IFILTSIISCVSSYKIL-LYSNLFGHSHVKVLAAAADILTDAGNNVTVLMPVFDNNLRNKTSLKS 70

  Fly    65 TITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQM-DSMLRKMADVLKDQRV 128
            |   ||...|......||:........|......:...|:::..:..| .:...:...|:.:..:
Worm    71 T---KNTIFVEAGPNVEELMSDMRQFLANAWKEDTGNPITMMKAAQDMGTAFAEQCTKVISEPGL 132

  Fly   129 KELYLNKDNHFDLVISGYFMN-DYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHDK-----VE 187
            .|..  |..::||.|:..|.. .|.|..|..:.|.|.:|..: ....:..:||.|...     .:
Worm   133 LEKL--KAENYDLAITEPFDTCGYALFEAINIRAHVAILTAN-RFDHVTDVIGQPIASSYVPGTQ 194

  Fly   188 KEKG--MTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSH 250
            .|.|  ||.|:||.:|...|:...|...|..|:.:....:.   |....:..||...|.:.
Worm   195 SETGDRMTMGERLGNYFQFLVGSYFFSLIGDRDFEAAKSVV---PITRSWRAILPEASFIL---- 252

  Fly   251 AASEGPI----RPSVPAAIEIGGIQIKDKPDPLPKNLE------KFLGNATHGAILLSLGSNVQG 305
             .::.|:    .|:....:.|||:.:|.:    .|||:      |.||...:. :.:|.|||.:.
Worm   253 -TNQIPLLDFPAPTFDKIVPIGGLSVKTE----KKNLKLDEKWSKILGIRKNN-VFISFGSNAKS 311

  Fly   306 SHIKADTVKKIFSVLSNLKQRV-IWKWDDL-DKTPGKSDNILYSRWLPQDDILAHPSVKLFINHA 368
            ..:..:....:..|..::.... |||:::. |......||:....||||:::||.|.:.:|:.|.
Worm   312 VDMPDEFKNSLADVFKSMPDTTFIWKYENTSDPIVNHLDNVHLGDWLPQNELLADPRLSVFVTHG 376

  Fly   369 GKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLE-ILSNPKYS 432
            |.|.::|....|.|.:.:|:|.||..||..:.:.|..:.:....|.:..|....|| ::.:|||.
Worm   377 GLGSVTELAMMGTPAVMIPLFADQGRNAQMLKRHGGAVVIEKNNLADTHFMKETLEKVIKDPKYL 441

  Fly   433 QRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAIS--- 494
            :...:.:.:..::|.:.:|:||.:.|:..|......|.:...|..:|....|||.|::..||
Worm   442 ENSKRLAEMLTNQPTNPKETLIKYVEFAARFGKLPSLDNYGRHQSYIEYFFLDIIAILAVISLFS 506

  Fly   495 -----IGLLLMLKKVVQITCRRLRTK 515
                 |.|..:::|:....|..:::|
Worm   507 LYISYIILRAVIRKIFFSKCSEVKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	112/464 (24%)
ugt-21	NP_001293944.1	UDPGT	32..526	CDD:278624	122/512 (24%)
ugt-21	NP_001293944.1	egt	<263..504	CDD:223071	64/245 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910