DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-48

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_504464.2	Gene:	ugt-48 / 178940	WormBaseID:	WBGene00015965	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	231/554 - (41%)	Gaps:	107/554 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT--VPMTKEEIKQRSET 89
            ||...|:.|.||:|....:|..||..||.   |...||..    :||..  ||..|   .:|...
Worm    20 ILMFSPTASKSHMISQGRIADELANAGHE---VVNFEPDF----LNLTDKFVPCKK---CRRWPV 74

  Fly    90 IGAKQKNTSSNRFISILN-MSG---QMDSMLRKM----ADVLKDQ---RVKELYLNKD------- 136
            .|     .::.:|..|.| :||   |..|:..|:    :|..:|:   ..:|:..||:
Worm    75 TG-----LNNYKFKKIQNGLSGDVFQQSSIWSKIFNTDSDPYQDEYTNMCEEMVTNKELIEKLKK 134

  Fly   137 NHFDLVISGYFMNDYQL---GFARKVNA-----------------PVVVLAPSPPSQMLNSLIGN 181
            ..||    .||.....|   |.|..:..                 .:.:..||.....:::|...
Worm   135 EKFD----AYFGEQIHLCGMGLAHLIGIKHRFWIASCTMSVSMRDSLGIPTPSSLIPFMSTLDAT 195

  Fly   182 PHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEI----------FGDDPTMPEYT 236
            |         ..|.||..:::..:.:          .|..|.::          ||.|....|:
Worm   196 P---------APFWQRAKNFVLQMAH----------IRDEYRDVVLTNDMFKKNFGSDFPCVEF- 240

  Fly   237 DILRNTSLVFFCSHAASEGPIR-PSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLG 300
             :.:.:.|:|..:....|  |: |::...:.|||:.:..:...|.:...|.:... .|.||.|||
Worm   241 -LAKTSDLIFVSTDELLE--IQAPTLSNVVHIGGLGLSSEGGGLDEKFVKIMEKG-KGVILFSLG 301

  Fly   301 SNVQGSHIKADTVKKIFSVLSNLKQ-RVIWKWDDLDK-----TPGKSDNILYSRWLPQDDILAHP 359
            :....:::....::.:..:....|. ..|.|.|..|:     ..|.| |:|...|:||..:||||
Worm   302 TIANTTNLPPTIMENLMKITQKFKDYEFIIKVDKFDRRSFDLAEGLS-NVLVVDWVPQTAVLAHP 365

  Fly   360 SVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEP--FRAAV 422
            .:|.||.|||...:.|:.|.|.|::.:|...|||.|..::.:.|:|:......|.::|  ...|:
Worm   366 RLKAFITHAGYNSLMESAYAGVPVILIPFMFDQPRNGRSVERKGWGILRDRFQLIKDPDAIEGAI 430

  Fly   423 LEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIY 487
            .|||.||.|.::..:...|.|.:|.||.|.|:..|.:|:.:.|...||....||||....||||
Worm   431 KEILVNPTYQEKANRLKKLMRSKPQSASERLVKMTNWVLENDGVEELQYEGKHMDFFTFYNLDI- 494

  Fly   488 ALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
             :|.|.||.:|:.:  |::|:...:.|...|.||
Worm   495 -IITAASIPVLIFI--VLRISNISIITSSPKNKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	120/487 (25%)
ugt-48	NP_504464.2	UDPGT	19..510	CDD:278624	139/537 (26%)
ugt-48	NP_504464.2	egt	<224..471	CDD:223071	71/252 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910