DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-9

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_504312.1	Gene:	ugt-9 / 178883	WormBaseID:	WBGene00020587	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	139/568 - (24%)
Similarity:	244/568 - (42%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVV----TVLEPT---ITHK 69
            :|::.|:|......|||...|....||......:|.|:|:.||||||.    ..|:.|   |.:|
Worm     6 LLSILLVISLVSCKNILVYNPIFGYSHAKFVSQLANIIADHGHNVTVFQPFHIALKNTDGLIKNK 70

  Fly    70 NINLVTV--PMTKEEIKQRSETI-----GAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQR 127
            ||.::..  ....|.:|:::.|.     .....|...:.|:....:.|:.:   :....:.:||:
Worm    71 NIEIINYYPDHYAELLKKKTPTFPDFWDSHLMNNPVLSSFLMPKALGGEFE---QTTTQLFQDQK 132

  Fly   128 VKELYLN--KDNHFDLV------ISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNP-- 182
            :    ||  |:.:||::      |:|:::.|.       :..|.:.|..:....:::|..|.|
Worm   133 I----LNDLKNRNFDVLLAETFEIAGFYIADL-------LEIPSIPLMSAVRLPIIDSAFGQPSI 186

  Fly   183 -------HDKVEKEKGMTFGQRLDSYISSLLYGIFLRQI-DQRNRQYYNEIF--GDDPTMPEYTD 237
                   :.||..|.|  |..||:.     ||.||...: .||..|:.|:..  .....:|.:.|
Worm   187 LGYFPQQYSKVAPEAG--FLDRLND-----LYRIFFWNLTTQRLCQFQNDFIQKAIGHPVPHWRD 244

  Fly   238 ILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT----------- 291
            :::.:.:....|::..:..: |:....:.:|||.|         :|||....|.
Worm   245 LVKESPIYITNSNSYLDFAV-PTTATIVHVGGITI---------DLEKMRHVAALTEEYENILAE 299

  Fly   292 -HGAILLSLGSNVQG----SHIKADTVKKIFSVLSNLKQRVIWKW--DDLDKTPGKSDNILYSRW 349
             ...:.:|.||.::.    .:.||..: |:|..|.::  ..|||:  ||:........|:...:|
Worm   300 RESTVFISFGSVIRSYEMPDNFKAGII-KMFKSLPDV--TFIWKYEKDDVKFQNRLPKNVHLKKW 361

  Fly   350 LPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLE 414
            :||..:||...||||:.|.|.|...|..|.|||.|.:|:|||||.||..:.:.|..:......|.
Worm   362 VPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPNNADMLARHGGAVAYDKFDLA 426

  Fly   415 E-EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVI---RHHGAAHLQSPLVH 475
            : |.....|.::::|.||.....:...:...:|...:.:|:...|:.:   :|..    |.|.::
Worm   427 DGEKLTKTVRDMVTNSKYEVNAQELLKVLSKQPIDPKLNLMKHLEFAMEFPKHRS----QVPAIN 487

  Fly   476 -MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
             ...||...||:..::...||..|.::.|::.|.  |....|.|||::
Worm   488 RTGLIAHYYLDVIGVLTLASIFGLFVIFKILNIL--RKMISLRKVKRE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	118/483 (24%)
ugt-9	NP_504312.1	egt	20..462	CDD:223071	117/475 (25%)
ugt-9	NP_504312.1	UDPGT	30..532	CDD:278624	131/541 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960