DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-24

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	132/562 - (23%)
Similarity:	241/562 - (42%)	Gaps:	94/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVIVLAL-------TLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTI 66
            ||.:..|       .:|||    :|:.|      .||:.:..:||..|.:.|||   ||:..|.|
Worm     7 FVFIFKLLNAALPYKILIY----SNLYG------HSHIKVLNTVADTLTDAGHN---VTIFRPII 58

  Fly    67 THKNINLVTVPMTK--------EEIKQRSETIGAKQ------KNTSSNRFISILN-MSGQMDSML 116
            ....::..:| .||        ||:.::...|....      .:|..:..|:..| :.|...:..
Worm    59 ESSQLDKSSV-KTKNVIYIEPDEEVVEKMSKIDQFSGSLWTFDSTHPSAMIAKSNALVGFFGTQC 122

  Fly   117 RKMADVLKDQRVKELYLNKDNHFDLVIS------GYFMNDYQLGFARKVNAPVVVLAPSPPSQML 175
            :|   |::.|::.:..  :|.:|||.|:      .|.:.:|     .|:...|.||: ......:
Worm   123 KK---VMRQQKILDQL--RDENFDLAITEPVDGCAYAIFEY-----LKIRDHVTVLS-CVRFDHV 176

  Fly   176 NSLIGNP-------------HDKVEKEKGMTFGQRLDSYISSLLYG--IFLRQIDQRNRQYYNEI 225
            :.::|.|             :|:      ||..:||.::| ...||  .|...:|| ..:...:|
Worm   177 SDILGQPIAPSYVPGTQSFFNDR------MTMKERLLNFI-QFYYGRFTFANILDQ-EYEMAKDI 233

  Fly   226 FGDDPTMPEYTDILRNTSLVFFCSHAASEGPI----RPSVPAAIEIGGIQIK--DKPDPLPKNLE 284
            .|   ....:.::|...|.:|     ::..|:    .|:....|.|||..:|  :|...:.|..:
Worm   234 LG---IQRSWREVLPEASFIF-----SNHIPVLDFPSPTFDKIIPIGGFTVKTNEKSLKIDKKWD 290

  Fly   285 KFLGNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRV-IWKWDDLDKTPGKS-DNILYS 347
            ..| |.....:|:|.|||.:...:..:..|.:..|.|::.... |||::|.:....|: ||:..|
Worm   291 AIL-NIRKKNVLISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYEDPNVNIAKNLDNVFIS 354

  Fly   348 RWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLT 412
            .||||:::||...|.:|:.|.|...:.|....|||.:.:|:|.||..||..:.:.|....|....
Worm   355 SWLPQNELLADSRVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHGGAAVLQKTD 419

  Fly   413 LEE-EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHM 476
            |.. :..|..:.::|:.|.|.....|.:.:..::|.:|:|.|:...|:..|......|.:...|.
Worm   420 LSNFDLVRDTLNDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLPMLDNYGRHQ 484

  Fly   477 DFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNK 518
            :.:....:||..:|.::.|.:..:..::::....|.|:..:|
Worm   485 NIVEYYFIDILTIILSVLISVFYIFVRLLRFMLSRNRSTKDK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	115/475 (24%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	121/518 (23%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	67/258 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910