DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	139/563 - (24%)
Similarity:	242/563 - (42%)	Gaps:	91/563 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLF-PSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITH------- 68
            ::||.||:.||..|....:| |.::.|.:.....||::||..||:||::     .::|
Worm     3 LIALFLLLLGAVSAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMI-----HLSHLPDYKTD 62

  Fly    69 ----KNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVK 129
                |||.:..|....|.:   ::.:..|:::....:...:.:|...| ||..:...:.:| ..:
Worm    63 VKIPKNIKVHRVEAYVEGL---TKALLEKEQSAFIFKDTGLKDMPAMM-SMFSRFGKMFQD-GCR 122

  Fly   130 ELYLNKD-------NHFDLVISGYFMNDYQLGF---------------------ARKVNAPVVVL 166
            .:..||:       ..||:..| |..:...:|.                     |..|..|::
Worm   123 NIVRNKEFMKWLENEKFDVAYS-YIYSSCPIGLIHAAKIPSWVWLNSGALMDFVAETVGVPII-- 184

  Fly   167 APS--PPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGD- 228
             ||  ||..|            |.:..|.|..|:.|:|...|..:..|::.....   .:||.|
Worm   185 -PSYVPPLMM------------ESDDEMGFFFRMKSFIGHTLMTVLHRRMTSNGE---TQIFRDE 233

  Fly   229 --DPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIK-DKPDPLPKNLEKFLGNA 290
              ||..|...|:.....||...|:...:.| ||::...:.|||:.:. |...||....:| :...
Worm   234 LNDPNFPHTMDLGAKCPLVIVNSNELYDLP-RPTLAKVVNIGGLGVGFDSAKPLTGEFKK-ISET 296

  Fly   291 THGAILLSLGSNVQGSHIK----ADTVKKIFSVLSNLKQRVIWKWDDL-DKTPGKSDNILYSRWL 350
            ..|.|:.|.|| |..:|..    .:::.:.||.|.:.:..:.:..||| |:.|   .|:...:||
Worm   297 GKGMIVFSFGS-VAAAHDMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDRLP---KNVHLFKWL 357

  Fly   351 PQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEE 415
            ||.|:|.|...|.||.|.|...:.||...|.|::::.:|||||.|:....|.||.:.:....:.:
Worm   358 PQKDLLLHNKTKAFITHGGYNSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISK 422

  Fly   416 EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIA 480
            :....|::||:.|..|.|:|.:.|::.|.:|....|.|:.|:|::.......:|:.....::|..
Worm   423 KTIVKAIMEIVENDSYKQKVSRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDNLEPAGQKLNFFQ 487

  Fly   481 ANNLDIYALIGAI-----SIGLLLMLKKVVQITCRRLRTKLNK 518
            .::||:...:..:     .||...|...:....|::..||..|
Worm   488 YHSLDVITFLFIVIFIVFYIGYRFMRAVIRCCFCKKCETKTKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	120/481 (25%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	125/517 (24%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	68/225 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910