DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	142/563 - (25%)
Similarity:	249/563 - (44%)	Gaps:	82/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVT-VVTVLEPTI--- 66
            :|.|::     |.:......|||...||...||......:|..|.|.||||| ||.|.:...
Worm     4 QSVFIL-----LSVINVNAFNILVYSPSFGGSHTNFMARLADTLTEAGHNVTFVVPVADEARKGQ 63

  Fly    67 --THKNINLVTV---PMTKEEIKQRSETIG----AKQKNTSSNRFISILNMSGQMDSMLRKMADV 122
              ..|..::|.|   .:.|.|||...:.:.    ....:::::...|:.:     |:||....:.
Worm    64 LGVKKTKDVVIVEQDELMKSEIKPLDDDMAQYWETDMDSSNADSIFSVFS-----DAMLLSCNNF 123

  Fly   123 LKDQRV-KELYLNKDNHFDLVISGYFMNDYQ------LGFARKVNAPVVVLAPSPPSQMLN---S 177
            :::::| .||   |..:||:.|       |:      ||:...:....::::.|  ..:.:   :
Worm   124 MRNKKVFNEL---KSRNFDVGI-------YEPLSVCGLGYMHAIGINKLIMSSS--CALYDGTVA 176

  Fly   178 LIGNPHD------KVEK--EKGMTFGQRLDSY-----ISSLLYGIFLRQIDQRNRQYYNEIFGDD 229
            .||.|.|      .:.|  || |:..::|::|     .|.:.||    |.| :..:.|.:..|:|
Worm   177 AIGEPIDFSYVPGSMSKSGEK-MSLFEKLENYRLSMASSRMQYG----QWD-KETEIYKKHLGND 235

  Fly   230 PTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQI---KDKPDPLPKNLEKFLGNAT 291
              :|.:.|::.::|:.|..|....:.| |......:.||||.:   ..|...|.......|....
Worm   236 --IPHWRDLMPSSSVAFTNSIPYVDFP-RSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERP 297

  Fly   292 HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQR----VIWKW--DDLDKTPGKSDNILYSRWL 350
            |. :|:|.||.|:...:   .:|....:|..:|..    .|||:  |:|:...| ..||.:|:|:
Worm   298 HN-MLISFGSMVRSMDM---PLKWRNGLLEAIKSEPNVTFIWKYENDNLEWAKG-IQNIYFSKWV 357

  Fly   351 PQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEE 415
            ||..:|....:..|:.|.|.|..:|..:.|||.|.:|||.||..||:.:.:.|..|.:....|..
Worm   358 PQTALLNDARLTAFMTHGGLGSTNELAFLGKPALMVPVFADQDRNANMLARHGGVLVVHKKELGN 422

  Fly   416 -EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFI 479
             :..::::..||...||.:...|.|.|..::|...:|.::.:||:|.:......:.|....:.||
Worm   423 FKTIKSSIRSILHEEKYQKNARKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFI 487

  Fly   480 AANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            ..|.:||||.|....:.::.::..|.:....:...||.|:.|:
Worm   488 QRNLIDIYAAISLSYLFVISLIYFVFKFVISKTPLKLVKLVKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/476 (26%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	128/508 (25%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	133/531 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910