DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	152/541 - (28%)
Similarity:	253/541 - (46%)	Gaps:	60/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALTLLIYGAQGANILG--LFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHK------ 69
            |.|.||:  |.|....|  |...:..||......|.:.|..:||.|.||.   |.::.:
  Rat    12 LGLCLLL--ASGFGHAGKLLVVPMDGSHWFTMQMVVEKLLPKGHEVVVVV---PEVSWQLGKPLN 71

  Fly    70 -NINLVTVPMTKEEIKQRSE-TIGAKQKNTSSNRFISILNMSGQ--MDSMLRKMADVLKDQRVKE 130
             .:...:|..|:|::.:..: .|.::.|.......:.:|....|  .:.:......:.||:::.|
  Rat    72 FTVKTYSVSHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFELLFSHCRSLFKDKKLVE 136

  Fly   131 LYLNKDNHFDLVISGYFMNDYQ---LGFARKVNAPVVVLA--------------PSPPSQMLNSL 178
             || |.:.||.|    |::.:.   |..|:..:.|.||.:              |||||.:
  Rat   137 -YL-KQSSFDAV----FLDPFDVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYV---- 191

  Fly   179 IGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTS 243
               |...::....|||.:|:.:.:|.:....|.....:......:|:.....||   ||:....|
  Rat   192 ---PRGILKLTDTMTFKERVWNLLSYMGEHAFCPSFFKTATDIASEVLQTPVTM---TDLFSPVS 250

  Fly   244 LVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGS 306
            :....:....|.| ||.:|..|.||||....: .||.|..|.:: ||:  ||.::.||||.|  |
  Rat   251 VWLLRTDFTLELP-RPVMPNVIHIGGINCHQR-KPLSKEFEAYV-NASGEHGIVVFSLGSMV--S 310

  Fly   307 HIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKG 371
            .|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|.||..:.||.|:|..
  Rat   311 EIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSH 374

  Fly   372 GISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVV 436
            ||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|:..:::|..|.:.::
  Rat   375 GIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIM 439

  Fly   437 KFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLM 500
            :.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||:...:.||.:.::.:
  Rat   440 RLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFI 503

  Fly   501 LKKVVQITCRRLRTKLNKVKK 521
            :.|.....||:......:|||
  Rat   504 VYKSCAYGCRKCFGGKGRVKK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/461 (27%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	143/521 (27%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	86/246 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910