Protein Alignment Ugt37A1 and UGT3A1

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_047272663.1
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 526
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 141/545 - (25%)
• Similarity: 248/545 - (45%)
• Gaps: 110/545 - (20%)

  Fly    34 LSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVTVPMTKEE---------------- 82
            |..||.::...|::||.|.|||||::        |::...: :|..|||
Human    34 LCGSHYLLLDRVSQILQEHGHNVTML--------HQSGKFL-IPDIKEEEKSYQVIRWFSPEDHQ 89

  Fly    83 --IKQRSETI------GAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKELYLNKDNHF 139
              ||:..::.      |.|:    |...:.::.:.|...|.|....|::...        |:.::
Human    90 KRIKKHFDSYIETALDGRKE----SEALVKLMEIFGTQCSYLLSRKDIMDSL--------KNENY 142

  Fly   140 DLVISGYFMNDY-QLGFARKVNAPVVVL-----------APSPPS--QMLNSLIGNPHDKVEKEK 190
            |||....|  |: ....|.|:..|.|.:           .|||.|  .:..||: ..|
Human   143 DLVFVEAF--DFCSFLIAEKLVKPFVAILPTTFGSLDFGLPSPLSYVPVFPSLL-TDH------- 197

  Fly   191 GMTFGQRLDSYISSLLYGIFLRQ-------IDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFC 248
             |.|..|:.::   |::..|.|.       .|...::::.|  |..|.:   :.:|....|.|..
Human   198 -MDFWGRVKNF---LMFFSFSRSQWDMQSTFDNTIKEHFPE--GSRPVL---SHLLLKAELWFVN 253

  Fly   249 SHAASEGPIRPSVPAAIEIGGIQIKDKP-DPLPKNLEKFLGN-ATHGAILLSLGSNVQGSHIKAD 311
            |..|.:. .||.:|..:.|||:.  :|| .|:|::|:.|:.| ...|.:|::.|| :..:|...:
Human   254 SDFAFDF-ARPLLPNTVYIGGLM--EKPIKPVPQDLDNFIANFGDAGFVLVAFGS-MLNTHQSQE 314

  Fly   312 TVKKIFSVLSNLKQRVIW-----KWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKG 371
            .:||:.:..::|.|.|||     .|   .:....:.|:....||||.|:|||||::||:.|.|:.
Human   315 VLKKMHNAFAHLPQGVIWTCQSSHW---PRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQN 376

  Fly   372 GISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVV 436
            .:.||..||.||:.|||.|||.||...:|...:|:::.|..:..:.....:.:::.:.:|...||
Human   377 SVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVV 441

  Fly   437 KFSSLYRDRPASARESLIFWTEYVIRHHGAAHL-----QSPLVHMDFIAANNLDIYALIGAISIG 496
            ..|.:...:|.|..:.|:.|.:::::..||.||     |.|. |..::    :|::..:..:::|
Human   442 AASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPW-HEQYL----IDVFVFLLGLTLG 501

  Fly   497 LLLMLKKVVQITCRRLRTKLNKVKK 521
            .:.:..|::.:..|.|| ...||||
Human   502 TMWLCGKLLGVVARWLR-GARKVKK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/473 (26%)
UGT3A1	XP_047272663.1	Glycosyltransferase_GTB-type	36..526	CDD:471961	140/543 (26%)