Protein Alignment Ugt37A1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 137/543 - (25%)
• Similarity: 235/543 - (43%)
• Gaps: 96/543 - (17%)

  Fly    33 SLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKN----INLVTVPMTKEEIKQRSETIGAK 93
            :|..||.:....:.:.|.::.|||||:........:.|    :|...:|            :..|
Human   237 ALDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIP------------VSYK 289

  Fly    94 QKNTSSNRFISILNMSGQMDSMLRKMADVLKDQR---------VKELYLNKDNHFDLVI---SGY 146
            :.|               :||::..|..:..|.|         .|||....|..|.:.|   .|.
Human   290 KSN---------------IDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGV 339

  Fly   147 FMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIG-------------NPHDKVEKEKG------- 191
            ..|...:...:|....|:|   :.|..:...|:.             :|...||:..|
Human   340 LKNPKLMARLQKGGFDVLV---ADPVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVS 401

  Fly   192 ------------MTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSL 244
                        ||||:|:.:.||..|.....:........||::|.|...|:.|   .:....:
Human   402 YVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTLCE---TMGKAEI 463

  Fly   245 VFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHI 308
            ....::...|.| ||.:|....:||:..| ...||||.:|:|: .:..:|.::.||||.|:  ::
Human   464 WLIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NL 524

  Fly   309 KADTVKKIFSVLSNLKQRVIWKWDDLDKTPGK-SDNILYSRWLPQDDILAHPSVKLFINHAGKGG 372
            ..:....|.|.|:.:.|:|:|::.  .|.|.. .:|.....|:||:|:|.||..|.||.|.|..|
Human   525 TEEKANLIASALAQIPQKVLWRYK--GKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNG 587

  Fly   373 ISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVK 437
            |.||.|||.||:.:|:|.|||.|...|...|..:.::|.|:......:|:..:::.|.|.:..::
Human   588 IYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMR 652

  Fly   438 FSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLK 502
            .|.::.|:|....:..:||.|:|:||.||.||:.....:.:...::||:   ||.:.:.:...:.
Human   653 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDV---IGFLLVCVTTAIF 714

  Fly   503 KVVQ---ITCRRLRTKLNKVKKQ 522
            .|:|   .:|::. .|:.|.||:
Human   715 LVIQCCLFSCQKF-GKIGKKKKR 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	116/472 (25%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	132/529 (25%)