Protein Alignment Ugt37A1 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 140/538 - (26%)
• Similarity: 240/538 - (44%)
• Gaps: 68/538 - (12%)

  Fly     5 TKSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHK 69
            |..:..::|.:.|..|.:.|:....|..:...||.:...::.|.|.::||.|||:......:...
Human     2 TLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSASILFDP 66

  Fly    70 N------INLVTVPMTKEEIKQRSETIGAKQ-KNTSSNRFISILNMSGQMDSMLRKMADVLKDQR 127
            |      ..:....:||.|.    |.|..:| |..|..|..|......|...:|.::.|:.:: .
Human    67 NDASTLKFEVYPTSLTKTEF----ENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFRN-F 126

  Fly   128 VKELYLNK-------DNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNPHDK 185
            .|::..||       ::.||:|            ||..|.....:||.....:.:.||...|...
Human   127 CKDVVSNKKVMKKLQESRFDIV------------FADAVFPCGELLAALLNIRFVYSLRFTPGYT 179

  Fly   186 VEKEKG-------------------MTFGQRLDSYISSLLYGIFLRQIDQRN-RQYYNEIFGDDP 230
            :|:..|                   |||.:|:.:.|..|.:..:.:..|.:. .|:|:|:.|...
Human   180 IERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRPT 244

  Fly   231 TMPE---YTDI-LRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNA 290
            |:.|   ..|| |...|..|...|        |.:|....:||...| ...||||.:|:|: .:.
Human   245 TLFETMGKADIWLMRNSWSFQFPH--------PFLPNVDFVGGFHCK-PAKPLPKEMEEFVQSSG 300

  Fly   291 THGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDI 355
            .:|.::.||||.:  |::.|:....|.:.|:.:.|:|:|::|. :|......|....:|:||:|:
Human   301 ENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDG-NKPDALGLNTRLYKWIPQNDL 362

  Fly   356 LAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRA 420
            |.||..:.||.|.|..||.||.|||.||:.:|:|.|||.|...|...|..:.|...|:.......
Human   363 LGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLN 427

  Fly   421 AVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLD 485
            |:..::::|.|.:.::|.|.:..|:|....:..:||.|:|:.|.||.||:.....:.:...::||
Human   428 ALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLD 492

  Fly   486 IYALIGAISIGLLLMLKK 503
            :...:.|....::.::.|
Human   493 VIGFLLACVATVIFIITK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/469 (26%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	135/516 (26%)