DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt5b1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001170964.2	Gene:	ugt5b1 / 100415791	ZFINID:	ZDB-GENE-100406-3	Length:	531	Species:	Danio rerio

Alignment Length:	567	Identity:	153/567 - (26%)
Similarity:	264/567 - (46%)	Gaps:	101/567 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLE--------PTI 66
            :::..|.:.:..||...:| :|| :..||.:....:.:.|..:|||:||:.:.:        |..
Zfish    12 ILIALLLVTVPTAQSEKVL-VFP-VDGSHWVNMNILVEALHAKGHNITVIRMADSWYIKEFSPHY 74

  Fly    67 THKNINLVTVPMTKEE------------IKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKM 119
            |  :|||.:.....||            :::.|.....|.:..:......::.:..:|      :
Zfish    75 T--SINLKSAGGFDEEFFETFAFRLMKIVREGSRWGRLKLEIETWQSTYEMIEIESEM------I 131

  Fly   120 ADVLKDQRVKELYLNKDNHFDL----------VISGYFMNDYQLGFARKV-----NAPVVVLAPS 169
            .::|:||.:.:.:  :|..:||          ||.|:|:   :|.....|     |....|.|||
Zfish   132 KNMLEDQPLMQTF--RDAKYDLLLTDPLLFGGVILGHFL---KLPIVYNVRWTMYNEAHFVSAPS 191

  Fly   170 PPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYI--------SSLLYGIFLRQIDQRNRQYYN--- 223
            |.|.:       |...||....|:|.||:.:.:        ::||:.           .|||
Zfish   192 PLSYV-------PFMMVELSDRMSFFQRVKNVVMFTVAEAQAALLFA-----------PYYNALC 238

  Fly   224 -EIFGDDP---TMPEYTDI-LRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNL 283
             :..|...   ::.:..|: |.....:|       |.| ||::|..|.:.|.|.|.. .|||::|
Zfish   239 EQFIGPGVSFLSLVQGADLWLHRVDFIF-------EYP-RPTMPNIIYMAGFQCKPS-KPLPQDL 294

  Fly   284 EKFL-GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGK-SDNILY 346
            |.|: .:..||.|::|||:.|  ..:..|..:.|....:.|.|::||::.  .|.|.. .:|.|.
Zfish   295 EDFVQSSGDHGVIIMSLGTLV--GQLPDDVAEAIAEAFAELPQKIIWRYK--GKRPSALGNNTLV 355

  Fly   347 SRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLL 411
            ..|:||:|:|.||..:.|:.|.|..|:.||.|||.|::...:..|||.|...|...|....:...
Zfish   356 MDWMPQNDLLGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLEKMRVRGAANNVDFA 420

  Fly   412 TLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHM 476
            |:::|.|...|.|:|.:|.|.:.:.:.|.|::|.|....::.|||.|:|:||.|||||::....|
Zfish   421 TMDKESFLKTVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKM 485

  Fly   477 DFIAANNLD-IYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            .:.:.:::| |..||.|:|: ::|.:..|::..|.|:..:..|||.|
Zfish   486 PWYSYHSVDVILVLISAVSL-IILTIYAVIRYFCCRICMRTTKVKLQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	124/483 (26%)
ugt5b1	NP_001170964.2	UDPGT	28..527	CDD:330975	146/545 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930