DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	550	Identity:	141/550 - (25%)
Similarity:	250/550 - (45%)	Gaps:	69/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEP---------- 64
            |..|:|..:....|..|||..:  ...||.|....|...|.::|||   ||||.|
Zfish     5 VCFLSLLTVFSAGQCGNILVWY--TEGSHWINLKIVLDTLLDRGHN---VTVLVPDGALFMKAKE 64

  Fly    65 --TITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISI----LNMSGQMDSMLRKMAD-V 122
              ..::::.::.......::...........:.:.||  |:.|    .|:..|...|.....| :
Zfish    65 SDRFSYQHFSVSKSAQDMQDFFDELMRFSVFEMDNSS--FLEIQMKFFNLGSQHQDMSLSYCDGI 127

  Fly   123 LKDQRVKELYLNKDNHFDLVISG--YFMNDYQLGFARKVNAPVVVL---------------APSP 170
            ||...:.:..  |...||:|:|.  |..:|.   .|.::|.|:|..               .|:|
Zfish   128 LKSPELMDKL--KKGKFDVVLSDPMYPCSDI---VAEELNVPLVYTFRFSVAHAAERMCGQIPAP 187

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEY 235
            ||.:..:: ....||      |:|.:|:.:.:..|......|.|.:|...||.|.||...:   |
Zfish   188 PSYVPGAM-SKLTDK------MSFTERIFNMLFYLSQDTLSRLIWRRFDNYYTEYFGRSTS---Y 242

  Fly   236 TDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSL 299
            .:::....:....::...|.| ||.||....|||:.. ....||||::|:|: .:...|.::.:|
Zfish   243 CEMMGKADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDGIVVFTL 305

  Fly   300 GSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLF 364
            ||.:  ..:..:...:|.|.|:.:.|:|:|::.. :|.....:|....:|:||:|:|.||..:.|
Zfish   306 GSMI--DKVPKEMSNRIASALAQIPQKVLWRYGG-EKPDTLGENTRIYKWIPQNDLLGHPKTRAF 367

  Fly   365 INHAGKGGISEAQYHGKPMLSLPVFGDQPGN-AHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSN 428
            |.|.|..|:.||.|||.||:.:|:|||||.| .|...::...:..|:.:::.:.....:..::::
Zfish   368 ITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVIND 432

  Fly   429 PKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAI 493
            |.|.:..::.|.::.|||....:..:||.|:|:|:.||.||:....::.:...:.||::|.:..:
Zfish   433 PSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTV 497

  Fly   494 SIGLLL-----MLKKVVQITCRRLRTKLNK 518
             :.|:|     |.|..:...|.|.:.|..|
Zfish   498 -LTLVLYICFKMAKFFIMRCCFRSKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	117/466 (25%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	135/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910