DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt1b5

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001170813.1	Gene:	ugt1b5 / 100384899	ZFINID:	ZDB-GENE-080227-14	Length:	528	Species:	Danio rerio

Alignment Length:	515	Identity:	148/515 - (28%)
Similarity:	247/515 - (47%)	Gaps:	57/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIISMSVAKILAEQGHNVTVVTVLEPTITHK---NINLVTVPMTKEEIKQRSETIG---AKQK 95
            ||.....:||:.:..:||.|.||.   |.|:.:   ..:.:|   .|..:|.:.:.:.   ||..
Zfish    40 SHWTGVKAVAEEMGRRGHTVIVVI---PEISMRLGPGKHYIT---KKFPVKYKPDVLNQMIAKLV 98

  Fly    96 NTSS-------NRFIS-ILNMSGQMDSMLRKMADVLKDQRVKELYLNKDNHFDLVISGYFMNDYQ 152
            ||.|       .|..| |.|....:|..:.....:.::|.:.|..  :|.:||.|::...|....
Zfish    99 NTLSAPEQSLLKRVTSNIYNFGKVVDYFISTTESLFQEQELIEFL--RDQNFDAVLTDPAMPTGA 161

  Fly   153 LGFARKVNAPVVVL------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSL 205
            : .|..::.|.|.:            .|.|||.:       |....:....|.||:||.:.::||
Zfish   162 I-LAYNLSVPAVYMLRGLMCESKATACPDPPSYI-------PRLFTQNSDHMNFGERLMNTLASL 218

  Fly   206 LYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAAS-EGPIRPSVPAAIEIGG 269
            :..:..:.......:..::....|.:|   |:|| :|..|:...:..: |.| :|.:|....|||
Zfish   219 MEPLMCKLKFSAFEEVTSKFLHRDVSM---TEIL-STGAVWLMRYDFTLEFP-KPLMPNITNIGG 278

  Fly   270 IQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQG-SHIKADTVKKIFSVLSNLKQRVIWKWD 332
            |.. :..:||.|.:|:|: |:..||.::.||||.|.. ...|||...|.||:   :.|||:|::
Zfish   279 INC-EVNNPLTKEVEEFVNGSGEHGIVVFSLGSLVSSMPKEKADIFFKAFSM---IPQRVLWRY- 338

  Fly   333 DLDKTPGK-SDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNA 396
             ..:.|.. .:|:...:||||:|:|.||..:.||.|.|..||.|...||.||:.||:||||..|.
Zfish   339 -TGEIPNNVPENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNV 402

  Fly   397 HAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVI 461
            |.:...|.|:.||:..:..|....|:..:::|..|.|::.|.|:::.|||....:..:||||:|:
Zfish   403 HRVATRGVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVM 467

  Fly   462 RHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            ||.||.||:.....::::..::||:...:..|.:.:.|.:.|...:..||...|..|.|:
Zfish   468 RHKGADHLRPAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLCWRRCCRKTQKRKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	127/448 (28%)
ugt1b5	NP_001170813.1	UDPGT	30..524	CDD:278624	146/510 (29%)
ugt1b5	NP_001170813.1	egt	<268..507	CDD:223071	87/244 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930