DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A1 and ugt2b1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001170809.1	Gene:	ugt2b1 / 100384895	ZFINID:	ZDB-GENE-100402-1	Length:	527	Species:	Danio rerio

Alignment Length:	551	Identity:	145/551 - (26%)
Similarity:	252/551 - (45%)	Gaps:	66/551 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEP---------- 64
            |..|:|..:....|..|||..:  ...||.|....|...|.::|||   ||||.|
Zfish     5 VCFLSLLTVFSAGQCGNILVWY--TEGSHWINLKIVLDTLLDRGHN---VTVLMPDGALFMKAKE 64

  Fly    65 --TITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSS-----NRFISILNMSGQMDSMLRKMADV 122
              ..::::.::.|.....::...........:...|:     .:|..:|  |...|..|.....:
Zfish    65 SDRFSYQHFSVSTSAQDMQDFLDEFLHFSVFELENSNLLQIQMKFFDLL--SKHQDMSLSYCDGI 127

  Fly   123 LKDQRVKELYLNKDNHFDLVISG--YFMNDYQLGFARKVNAPVVV-----LA----------PSP 170
            ||...:.:..  |...||:::|.  |..:|.   .|.::|.|:|.     ||          |:|
Zfish   128 LKSPELMDKL--KKGKFDVLLSDPMYPCSDI---VAEELNVPLVYTFRFSLAHTMERMCGQIPAP 187

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEY 235
            ||.:       |....:....|:|.:|:.|.:..|....|.|.|.:|...||.|..| .||  .|
Zfish   188 PSHV-------PGATSKLTDKMSFTERICSMLFYLSIDTFYRLIWKRFDNYYTEYLG-RPT--SY 242

  Fly   236 TDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSL 299
            .:::....:....::...|.| ||.||....|||:.. ....||||::|:|: .:...|.::.:|
Zfish   243 CEMMGRADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDGIVVFTL 305

  Fly   300 GSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLF 364
            ||.:  ..:..:...:|.|.|:.:.|:|:|::.. :|.....:|....:|:||:|:|.||..:.|
Zfish   306 GSMI--DKVPKEMSNRIASALAQIPQKVLWRYGG-EKPDTLGENTRIYKWMPQNDLLGHPKTRAF 367

  Fly   365 INHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTL-SLLTLEEEPFRAAVLEILSN 428
            |.|.|..||.||.|||.||:.:|:|||||.|...|...|..:.: |:.:::.:.....:..::::
Zfish   368 ITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLNTVIND 432

  Fly   429 PKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAI 493
            |.|.:..::.|.::.|||....:..:||.|:|:|:.||.||:....::.:...:.||::|.:..:
Zfish   433 PSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTV 497

  Fly   494 SIGLLLMLKKVVQITCRR--LRTKLNKVKKQ 522
            ...:|.:..|:.:....|  .|:| .|.||:
Zfish   498 LTLVLYICSKMAKFFIMRCCFRSK-RKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	121/466 (26%)
ugt2b1	NP_001170809.1	UDPGT	20..523	CDD:278624	138/530 (26%)
ugt2b1	NP_001170809.1	egt	<264..497	CDD:223071	73/236 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000