DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt1b2

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001170807.1	Gene:	ugt1b2 / 100384893	ZFINID:	ZDB-GENE-080227-11	Length:	531	Species:	Danio rerio

Alignment Length:	518	Identity:	145/518 - (27%)
Similarity:	245/518 - (47%)	Gaps:	61/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIISMSVAKILAEQGHNVTVV----TVLEPTITHKNINLVTVPMTKEEIKQRSETIGAK--QK 95
            ||.....:||:.:..:||.|.||    :||.....|....:.:|   |.:.|..::.:..:  :.
Zfish    41 SHWTGVKAVAEEMGRRGHTVIVVIPEISVLLGPGQHYITKMFSV---KYDQKSLNKVLNERVLEV 102

  Fly    96 NTSSNRFIS-----ILNMSGQMDSMLRKMADVLKDQRVKELYLNKDNHFDLVISGYFMNDYQLG- 154
            ....|.|:|     :.|:....::|......:.:|:.:.|...|:  :||.|::...:   .:|
Zfish   103 TNPGNSFLSTVIRIVSNLRRMFNTMAATSESLFQDKELIESLRNE--NFDAVLTDPVL---PMGA 162

  Fly   155 -FARKVNAPVVVL--------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISS 204
             .|..::.|.|.|              .|:|.|.:       |.........|:||:|:.:.:.|
Zfish   163 ILAYNLSVPAVYLLRGMACGLDATATTCPNPSSYI-------PRFHTRNTDRMSFGERVMNMLMS 220

  Fly   205 LLYGIFLRQIDQRNRQYYNEIFG---DDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIE 266
            :|.....:.:   .|.:...||.   .|.:|   |:|||..::.........|.| :|.:|....
Zfish   221 ILEQTVCKFM---YRSFEEMIFNFLQRDVSM---TEILRTGAVWLMRYDFTLEFP-KPLMPNMQF 278

  Fly   267 IGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQG-SHIKADTVKKIFSVLSNLKQRVIW 329
            ||||....: :||.|.:|:|: |:..||.::.||||.|.. ...|||...|.||:   :.|||:|
Zfish   279 IGGINCGVR-NPLTKEVEEFVNGSGEHGIVVFSLGSLVSSMPKEKADIFFKAFSM---IPQRVLW 339

  Fly   330 KWDDLDKTPGK-SDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQP 393
            ::  ..:.|.. .:|:...:||||:|:|.||..:.||.|.|..||.|...||.||:.||:||||.
Zfish   340 RY--TGEIPNNVPENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQA 402

  Fly   394 GNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTE 458
            .|.|.:...|.|:.||:..:..|....|:..:::|..|.|::.|.|:::.|||....:..:||||
Zfish   403 DNVHRVATRGVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTE 467

  Fly   459 YVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :|:||.||.||:.....::::..::||:...:..|.:.:.|.:.|...:..||...|..|.|:
Zfish   468 FVMRHKGADHLRPAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLCWRRCCRKTQKRKE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	124/451 (27%)
ugt1b2	NP_001170807.1	UDPGT	31..527	CDD:278624	143/513 (28%)
ugt1b2	NP_001170807.1	egt	<271..510	CDD:223071	87/244 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930