DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt1a6

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001107366.1	Gene:	ugt1a6 / 100135191	XenbaseID:	XB-GENE-5793241	Length:	531	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	147/563 - (26%)
Similarity:	239/563 - (42%)	Gaps:	100/563 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTV----VTVLEPTITHK 69
            |.|:|||..    |.|..:| :.|. ..||.:....:...||::||.:.|    |.:|...:.:.
Frog    16 FFILLALGC----ADGGRLL-VVPQ-DGSHWLSMRVLVDRLAQRGHYIVVAIPEVNMLFKDLDNY 74

  Fly    70 NINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISIL----------NMSGQMDSMLRKMADVLK 124
            .:...:.|.:|:.::.|       .:..:...|:..:          :||.....::......|:
Frog    75 KVKTFSSPYSKDVLENR-------MRRMNQEIFVDRILTEKITFWYESMSNATQWVVSACQHFLQ 132

  Fly   125 DQR-VKELYLNKDNHFDLVI------------------SGYFMNDYQLGFARKVNAPVVVLAPSP 170
            :.. ::||   :..|||.::                  |..||.....|..:     :....|||
Frog   133 NSTLIREL---EKEHFDAMLTDSVFPCGEIVAEHLSIPSVSFMRGTIFGMDQ-----IASQTPSP 189

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSY----ISSLLYGIFLRQIDQRNRQYYNEIFGDDPT 231
            ||.:       |.........|:|.||:.::    :..::..||          ||       |.
Frog   190 PSYV-------PRMFTVYTDNMSFSQRVKNFLIHSLEHIVCHIF----------YY-------PY 230

  Fly   232 MPEYTDILR----------NTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKF 286
            ....:|.|:          .||:.........|.| ||.:|..|.||||... |...||:..||.
Frog   231 AQMASDFLKKEVTAMSLFSRTSIWLMRYDFVFEFP-RPIMPNVILIGGINCA-KQKALPQEFEKL 293

  Fly   287 L-GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWL 350
            : .:..||.::.|.||.|  |.|..:....|...|..:.|:|.|::.. ...|...||....:||
Frog   294 VKSSGEHGFVVFSFGSMV--SEIPMNIAMDIAEALRYIPQKVFWRYTG-KAPPNLGDNTHLVKWL 355

  Fly   351 PQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEE 415
            ||:|:||||..:.||.|||..|:.|...:..||:.||:.|||..||..:...|.||.|::..|..
Frog   356 PQNDLLAHPKARAFITHAGSHGVYEGICNAVPMVMLPLIGDQMDNAKRIESRGAGLILNVQNLIP 420

  Fly   416 EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFI 479
            :....||:.::.||.|.:.:.:.|||:||||....:..:.|.|:|::|.||.||: |..| :::|
Frog   421 DDLSNAVMAVIDNPSYKENIQRLSSLHRDRPVQPLDLAVHWVEFVMKHKGAPHLR-PAAHDLNWI 484

  Fly   480 AANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            ...:||:.|.:.|:.:..|.:..|.....||....:..|.|::
Frog   485 QYQSLDVMAFLLAVLLTTLFISLKCSTFACRCCCKRNTKPKRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	119/478 (25%)
ugt1a6	NP_001107366.1	UDPGT	28..527	CDD:278624	140/545 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910