DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and ARHGEF7

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001340975.1	Gene:	ARHGEF7 / 8874	HGNCID:	15607	Length:	862	Species:	Homo sapiens

Alignment Length:	836	Identity:	256/836 - (30%)
Similarity:	396/836 - (47%)	Gaps:	207/836 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            |||:|:::|..:|.|||.|.|||||.||:.|:|||||||||.:|||||||||.|.|..    .|.
Human   166 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPK 230

  Fly    66 TETIR-PPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :.|:: ||:..      :.|.:|||:::|::|..:..|||.:|..:|.|:|.::.||....:.||
Human   231 SGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLM 295

  Fly   124 CNFVEIVRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .|..||....:.|:..:|||      ..|||..||...|.||.::..|||.||.|:.:|.::.:|
Human   296 GNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |.::||.:||::||:|||||||||||.|||||..:|:|||||||..|.||.|.|:|:|.:|:::|
Human   361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 425

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLFL 308
            .|...|::||||||:||..:|.|:|.::.|||::.:|..|.:   |::.: :||.:|||..||.|
Human   426 QCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLML 490

  Fly   309 SVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELL--- 370
            |.|.|||.|||:||||.||:.:.:|||::..:||||||..:|:||:..|....:..:|||.|
Human   491 SASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQ 555

  Fly   371 ----NANNPSLPMGIKRQLSNLSNSSLGHLNAAH----LSQHLDSRGYCTRFSLCAYYSSPPCHV 427
                :..||::.          .:|...|...:|    .|:|.||:               |..:
Human   556 TKVTSVGNPTIK----------PHSVPSHTLPSHPVTPSSKHADSK---------------PAPL 595

  Fly   428 RPLRVTLP-PSNY--------------PATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQS 477
            .|...||| ||::              |.|....:||.          ||.|       |..|.|
Human   596 TPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSC----------LRPA-------PPLRPS 643

  Fly   478 IDLKRIALRKRRCHKASAKLKDLNTNQDSGQSELERQDAIELPTDSE----SYDDDFEDDFLHSC 538
            ..|         |:|     :||:.:..:.:..|.::.....|:|.|    ......|:
Human   644 AAL---------CYK-----EDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEE------ 688

  Fly   539 DSDPFEYVQFY-QNKRNDSMCNST--GTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKE 600
            |:...:.::.| .:.:.....|||  ||.:.|     .|.         .||.|:
Human   689 DAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH-----NHV---------LADDDQ---------- 729

  Fly   601 SLVIGSRALRALARKSTTRNSSVHTSTATLELGVGGSITNCVEEEPILKVKPSFSLQQQSSDASS 665
                  .:|.:|.|:|:                             :.:::||.  ..:.||..|
Human   730 ------PSLDSLGRRSS-----------------------------LSRLEPSD--LSEDSDYDS 757

  Fly   666 IFAA---RLGGAFTACENLASMPDDLSRESS---IQEPPTPLPASPTERHSMPTIFVGNRFNHSK 724
            |:.|   |:|.  |:.....|.|..|..|..   ::|..:.......|:..:.|::.
Human   758 IWTAHSYRMGS--TSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYA-------- 812

  Fly   725 NTEVYVPTWRDRQEMQNQSVDAKQDEELHSSSIDLPAACLSAPDKLQAELLYNYDE 780
                          ::::..:.:||.:....|::.........:||..::|.|.::
Human   813 --------------LKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	35/51 (69%)
		RhoGEF	79..249	CDD:238091	79/175 (45%)
		PH_Cool_Pix	281..376	CDD:269932	43/105 (41%)
ARHGEF7	NP_001340975.1	CH	21..107	CDD:237981
		RhoGEF67_u1	117..163	CDD:318756
		SH3_betaPIX	167..220	CDD:212994	35/52 (67%)
		RhoGEF	251..428	CDD:238091	79/176 (45%)
		PH_Cool_Pix	459..557	CDD:269932	42/97 (43%)
		Atrophin-1	<562..>643	CDD:331285	25/122 (20%)
		RhoGEF67_u2	613..711	CDD:318755	22/134 (16%)
		betaPIX_CC	773..859	CDD:318676	14/104 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4154
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251777at33208
OrthoFinder	1	1.000	-	-		FOG0002550
OrthoInspector	1	1.000	-	-		otm40260
orthoMCL	1	0.900	-	-		OOG6_103985
Panther	1	1.100	-	-	O	PTHR46026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3079
SonicParanoid	1	1.000	-	-		X1675
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.950