Protein Alignment RtGEF and vav2

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_017208431.2
• Gene: vav2 / 556413
• ZFINID: ZDB-GENE-091204-420
• Length: 880
• Species: Danio rerio
• Alignment Length: 754
• Identity: 149/754 - (19%)
• Similarity: 251/754 - (33%)
• Gaps: 248/754 - (32%)

  Fly    79 RSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIE-- 141
            |:..|.::.::|..:...|:.:.:|::.|::  |:|:..|...:..|..:|:|.|..||..|:
Zfish   200 RNCCLVEIQETEAKYYKTLEDIEKNYMIPLK--QVLTPQEMEAIFVNLEDIIRVHFALLRAIDLT 262

  Fly   142 --ECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKY----KDELEKYMERQGAATPGLLVL 200
              ...:.:||:||.....: .::..||:....|...||:.    :|...|..|.......|...|
Zfish   263 MVSGGNGLGKIFLDFKERL-LIYGQYCSHMENAQKTLDELIATREDVKCKVEECTMKVQEGKFKL 326

  Fly   201 TTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKEL--ELQVL 263
            ...|..|.:|:.||..:|:||..| ....|:|...:.::...:|:|...:..:|..|.  ::...
Zfish   327 QDLLVVPMQRVLKYHLLLKELVSH-SMDRPERQQLKEALEAMQDLAMYINEVKRDNETLKKISEF 390

  Fly   264 TGPVRGWQGQELSTLGDIIHMGSV----AVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYE---- 320
            ...:...| .:|...|.....|.:    .|....:|||..||.:.::   |.:| ..:.||
Zfish   391 QSSIENLQ-VKLEEYGRPKIDGELKVCSIVNRTKQDRYIFLFDKVVI---VCKR-KGYNYELKEV 450

  Fly   321 ----------------------GKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEA 363
                                  ||:...|..:..|:.    |..|:.          .|:..:..
Zfish   451 IELHLYKMSDDPMNNRDMKKSSGKMWSYGFYLIHLQG----KQGFQF----------FCKTEDTK 501

  Fly   364 NKWVELL------------NANNPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRG-YCTRFS 415
            .||:|..            .||..:..|....:.:|.....:       |.:.:..:| ||   |
Zfish   502 RKWMEQFEMAMSNIKPERATANQHNFQMHTFEKNTNCRACKM-------LLRGIFYQGYYC---S 556

  Fly   416 LCAYYSSPP-------CHVRP--LRVTLPPS--------NY------PATAPYANLSAHFARLVK 457
            ||...:...       |.:.|  ....||.|        ||      |...|....:.....|:|
Zfish   557 LCGTGAHKECLEIITICKISPHDSEPGLPQSGPKMVAIRNYHGAPAPPGKIPLCFQTGEVIELLK 621

  Fly   458 G-----------------GGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQD 505
            |                 |...|:.||..|.|:..|:                      .:..|.
Zfish   622 GDPDTSWWEGKLIQTQKTGYFPSSSVKPCLDPKPFQA----------------------FSNRQS 664

  Fly   506 SGQSE----------LERQDAIELPTDSESYDDDFEDDFLHSCDSDPFEYVQFYQNKRNDSMCNS 560
            |.:::          :|||.|               |:.|.|                     :|
Zfish   665 SRETDYYVYPWFAGNMERQQA---------------DNLLKS---------------------HS 693

  Fly   561 TGTFV--DHGTGARRHCSSINL------IKLDSADTDEVLALNELKK-ESLV-----IGSRALRA 611
            :||::  :....|.|...||..      ||:  .:.|..:.:.|.|| |||:     ..|.:|:.
Zfish   694 SGTYLIRERTAEAERFAISIKFNDEVKHIKV--IEKDNWIHITEAKKFESLLELVEYYQSHSLKE 756

  Fly   612 LAR----------KSTTRNSSVHTSTATLELGVGGSITNCVEEEPILKVKPSFSL---------Q 657
            ..:          ||..|:|| .|:|.:       ....|...        :||.         .
Zfish   757 SFKLLDTTLRYPYKSRERSSS-RTNTRS-------PAATCASY--------NFSFLSPQGLNFSS 805

  Fly   658 QQSSDASSIFAARLGGAFTACENLASMPDDLSRESSIQE 696
            |.|:...|:|..|:.....|..|.|:.  |: ||.|::|
Zfish   806 QSSAPFWSVFTPRVVSTAVARYNFAAR--DM-RELSLRE 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810
		RhoGEF	79..249	CDD:238091	43/177 (24%)
		PH_Cool_Pix	281..376	CDD:269932	23/136 (17%)
vav2	XP_017208431.2	None