Protein Alignment RtGEF and arhgef7a

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_021334338.1
• Gene: arhgef7a / 553493
• ZFINID: ZDB-GENE-060322-11
• Length: 864
• Species: Danio rerio
• Alignment Length: 716
• Identity: 229/716 - (31%)
• Similarity: 355/716 - (49%)
• Gaps: 133/716 - (18%)

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            |||:|.::|..:|.|||.|.|||:|:||:.|:||||||.||.||||||||||.|.|..    .|.
Zfish   171 LVVKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGKTGWFPSNYVKEVKGSDKQVSPK 235

  Fly    66 TETIRPPEE-------IQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :..::.|.:       .:.|.::||:::|::|..:..|||.||.::|.|:|.|:.||..:.:.::
Zfish   236 SGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADVSVIL 300

  Fly   124 CNFVEI-------VRTHEDLLIQIEECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKD 181
            .|..||       |::.|| |.::.|...:||..||...|.|:.::.:||:.||..:.:|..:.:
Zfish   301 GNLEEISTFQQTLVQSLED-LTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPSTVNVLTVHSE 364

  Fly   182 ELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIA 246
            ||.::||.:||:.||:|.||:||||||.|||:|..:|:|||||||..||||.:.|:.:..:|:::
Zfish   365 ELGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLS 429

  Fly   247 ATCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLF 307
            |.|...|::||||||:|...:|.|:|:::.|||.:::|....|   |.:.: :||.:|||..||.
Zfish   430 AQCQEVRKRKELELQILAETIRLWEGEDIKTLGSVLYMSQAMVQNHGCEEKNERYLLLFPHVLLI 494

  Fly   308 LSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNA 372
            ||.|.|||.|||:|||||:|:.|..|||.::.|:|||:|..:.:|:..:|....:.:.|:|.||.
Zfish   495 LSASPRMSGFIYQGKLPLSGMTVTPLEDCESHKDAFELSGSMFERLQVICYNKQDLHDWLEHLNR 559

  Fly   373 NN--------------------PSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRG--YCTR-- 413
            ..                    ||.|:...|   :..:..|....|.|...|..|.|  :.|.
Zfish   560 QTKHTTMAAPSMKPLTVPCHTLPSHPLTPSR---HGESRGLTVAPAYHTLPHPSSHGTPHSTMMW 621

  Fly   414 -----------FSLCAYYSSPPCHVRP----------------LRVTLP---PSNYPATAPYANL 448
                       :||.....:||  :||                ::..||   |...|:...:|
Zfish   622 GPLEPPKTQKPWSLSCLRPAPP--LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFA-- 682

  Fly   449 SAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTN---QDSGQSE 510
                        ||.:.|.:....|..:.|:....:.:.|:...::.:..||..|   ..|....
Zfish   683 ------------LRKSTVALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLDQSSADS 735

  Fly   511 LERQDAIELP--TDSESYDDDFEDDF-LHSC----------DSDPFEYVQFYQNKRNDSMCNSTG 562
            |.|:.:|..|  |...|.|.|::..: .||.          |..|...|...:....|.:.::..
Zfish   736 LGRRSSISRPEATSDLSEDSDYDSIWTAHSYRMGSVTRQWKDGSPALIVPGDEKFSVDELKSNGQ 800

  Fly   563 TFVDHGTGARRHCSSINLIKLDSADTDEVLALNELK------KESLVIGSRALRALAR--KSTTR 619
            |.::..          :|:.:..|..|||   .|||      |:||....||.:.|.|  |...:
Zfish   801 TLLEEK----------SLVDVVYALRDEV---QELKQDYKKMKKSLEEEQRARKDLERIVKKMLK 852

  Fly   620 N 620
            |
Zfish   853 N 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	34/51 (67%)
		RhoGEF	79..249	CDD:238091	70/176 (40%)
		PH_Cool_Pix	281..376	CDD:269932	40/118 (34%)
arhgef7a	XP_021334338.1	CH_SF	4..114	CDD:469584
		RhoGEF67_u1	116..168	CDD:465201
		SH3_alphaPIX	170..226	CDD:212993	36/54 (67%)
		RhoGEF	256..433	CDD:238091	70/177 (40%)
		PH_Cool_Pix	464..562	CDD:269932	40/97 (41%)
		RhoGEF67_u2	621..711	CDD:465200	16/105 (15%)
		betaPIX_CC	779..863	CDD:465158	21/88 (24%)