DRSC/TRiP Functional Genomics Resources

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Protein Alignment RtGEF and Kalrn

DIOPT Version :10

Sequence 1:NP_001097184.2 Gene:RtGEF / 35306 FlyBaseID:FBgn0015803 Length:1310 Species:Drosophila melanogaster
Sequence 2:XP_011244253.1 Gene:Kalrn / 545156 MGIID:2685385 Length:2999 Species:Mus musculus


Alignment Length:727 Identity:145/727 - (19%)
Similarity:271/727 - (37%) Gaps:223/727 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 DGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPP------EEIQEYRSV-----VLKDLLDS 89
            :||.:.|:|.|.||         |     |.|.:.||      ||.|:.:::     ||.:|:.:
Mouse  1896 E
GGSYRGSLKDPTG---------C-----LNEGMTPPTPPRNLEEEQKAKALRGRMFVLNELVQT 1946

  Fly    90 ERAHVAELQGLLENFLEPMQQTQILSQDEYAQ---LMCNFVEIVRTHED-LLIQIEEC---NDRV 147
            |:.:|.:|..::|.|::.:::..: .:|...:   :..|..:|...|:| .|.::|:|   .||:
Mouse  1947 EKDYVKDLGIVVEGFMKRIEEKGV-PEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRL 2010

  Fly   148 GKLFLTSAPLMKKVH--QAYCAAHPKAIVIL---DKYKDELEKYMERQGAATPGLLVLTTGLSKP 207
            .:||:...   :|:|  ..||...|::..|:   |.|.:|:::.:.::       |.|:..|.||
Mouse  2011 AQLFIKHE---RKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQR-------LTLSDFLIKP 2065

  Fly   208 FRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQG 272
            .:|:.||..:|::..|:.|.:..:..|.:::|.:      .|...:|..::   :..|.::|::|
Mouse  2066 IQRITKYQLLLKDFLRYSEKAGLECSDIEKAVEL------MCLVPKRCNDM---MNLGRLQGFEG 2121

  Fly   273 QELSTLGDIIHMGSVAV-----GADHR--DRYFVLFPQTLLFLSVSQRMS---AFIYEGKLPLTG 327
             .|:..|.::...:..|     |...|  :|...||.|.::|..:.::.|   .::::..:.:..
Mouse  2122 -TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNY 2185

  Fly   328 IIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSS 392
            :::....|.|..|.|      |::|         |.::.| :|.|.|..:.....:.::.:..:.
Mouse  2186 LVLEDNVDGDPCKFA------LMNR---------ETSERV-ILQAANSDIQQAWVQDINQVLETQ 2234

  Fly   393 LGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTLPPSNYPATAPYANLSAHFARLVK 457
            ...|||                     ..||..:.|..|.|....:.|...|.|:     .|...
Mouse  2235 RDFLNA---------------------LQSPIEYQRKERSTAVIRSQPPRVPQAS-----PRPYS 2273

  Fly   458 GGGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQDSGQSELERQDAIELPTD 522
            .|.:.|                                                      |.|..
Mouse  2274 SGPVGS------------------------------------------------------EKPPK 2284

  Fly   523 SESYDDDFEDDFLHSCDSDP-FEYVQ----FYQNKRND-SMCNSTGTFV---DHGTGARRHCSSI 578
            ..||:.......:.:.:..| |:|.|    |..:|:|| ..||.|.|..   |:      :....
Mouse  2285 GSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQNDLGGCNGTSTMTVIKDY------YALKE 2343

  Fly   579 NLIKLDSADTDEVLALNELK--------------KESLVIGSRALRALARKSTTRNSS-----VH 624
            |.|.:...:..:|||:|:..              .|..|.|| .|..||:.:....||     ..
Mouse  2344 NEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGS-ILAPLAKATAAAESSDGSIKKS 2407

  Fly   625 TSTATLELGVGGSITNCVEEEPILKVKP------SFSLQQQSSDASSIFAARLGGAFTACENLAS 683
            .|..||.:.....:.|..:.|.....||      ..|:::.:|...|           .|     
Mouse  2408 CSWHTLRMRKRADVENSGKNEATGPRKPKDILGNKVSVKETNSSEES-----------EC----- 2456

  Fly   684 MPDDLSRESSIQ 695
              |||...:|::
Mouse  2457 --DDLDPNTSME 2466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RtGEFNP_001097184.2 SH3_PIX 6..58 CDD:212810 7/21 (33%)
RhoGEF 79..249 CDD:238091 42/186 (23%)
PH_Cool_Pix 281..376 CDD:269932 20/104 (19%)
KalrnXP_011244253.1 PH1_Kalirin_Trio_like 1469..1591 CDD:270060
SH3_Kalirin_1 1657..1716 CDD:212786
SH3-RhoG_link 1714..1896 CDD:465196 145/727 (20%)
RhoGEF 1939..2108 CDD:459876 44/185 (24%)
PH2_Kalirin_Trio_p63RhoGEF 2113..2247 CDD:270061 30/171 (18%)
SH3_Kalirin_2 2331..2387 CDD:212787 12/62 (19%)
I-set 2478..2572 CDD:400151
Ig strand B 2495..2499 CDD:409353
Ig strand C 2508..2512 CDD:409353
Ig strand E 2538..2542 CDD:409353
Ig strand F 2552..2557 CDD:409353
Ig strand G 2565..2568 CDD:409353
FN3 2576..2667 CDD:238020
STKc_Kalirin_C 2697..2944 CDD:271017
SEC14 47..185 CDD:214706
SPEC 198..418 CDD:238103
SPEC 319..544 CDD:238103
SPEC 545..774 CDD:238103
SPEC 899..1137 CDD:238103
SPEC 1143..1243 CDD:197544
RhoGEF 1292..1462 CDD:238091
Blue background indicates that the domain is not in the aligned region.

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