DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RtGEF and Arhgef6

DIOPT Version :9

Sequence 1:NP_001097184.2 Gene:RtGEF / 35306 FlyBaseID:FBgn0015803 Length:1310 Species:Drosophila melanogaster
Sequence 2:XP_008771873.1 Gene:Arhgef6 / 363509 RGDID:1359674 Length:789 Species:Rattus norvegicus


Alignment Length:654 Identity:213/654 - (32%)
Similarity:322/654 - (49%) Gaps:152/654 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECK-VQLPLTET 68
            |:|:|.::|..:|.|||...|||:|.||:.|:|||||||||.:|||||||||.|.| .:.||:  
  Rat   187 LIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKPSERPLS-- 249

  Fly    69 IRPPEEI---------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMC 124
               |:.:         :.|.:|||:::||:|:.:..|||.||..:|.|:|....||..|:..|:.
  Rat   250 ---PKAVKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEFTCLLG 311

  Fly   125 NFVEIVRTHEDLLIQIEECN------DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDEL 183
            ||.|:....:.|...:|||:      .:||...|...|..|.::.||||.||.|:.:|.::.|:|
  Rat   312 NFEEVCTFQQTLCQALEECSKSPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDDL 376

  Fly   184 EKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAAT 248
            |::||.|||::||:|:|||.|||||.||:||..:|||||||||.:|||..|..:::..:|.:...
  Rat   377 ERFMENQGASSPGILILTTSLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKSLMGQ 441

  Fly   249 CSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV--GA--DHRDRYFVLFPQTLLFLS 309
            |...|::|:||||:|:.|::.|:|.::.|||::|.|..|.:  ||  :..:|||:||...|:.||
  Rat   442 CQDLRKRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGACEEKEERYFLLFSSVLIMLS 506

  Fly   310 VSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLN--A 372
            .|.|||.|:|:||:|:.|::|.||::.:.....|||:...::|||..|....:..:|:|.||  .
  Rat   507 ASPRMSGFMYQGKVPIAGMVVTRLDEIEGNDCTFEITGSTVERIVVHCNNNQDFQEWMEQLNRLT 571

  Fly   373 NNPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSS---------PPCHVR 428
            ..|:            |.|||...:::..|.|             :.:||         ||..::
  Rat   572 KGPA------------SCSSLSKTSSSSCSTH-------------SSFSSTGQPRGPLEPPQIIK 611

  Fly   429 PLRVT----LPPSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIALRKRR 489
            |..::    .||....|...|...|:...:.:|         |.|                    
  Rat   612 PWSLSCLRPAPPLRPSAALGYKEESSKSPKTMK---------KFL-------------------- 647

  Fly   490 CHKASAKLKDLNTNQDSGQSELERQDAIELPTDS------ESYDDDFEDDFLHSCDSDPFEYVQF 548
             ||...:.|      .|.:..:.|:....|..|:      |:|           |.|     ..|
  Rat   648 -HKRKTERK------TSEEEYVIRKSTAALEEDAQILKVIEAY-----------CTS-----ASF 689

  Fly   549 YQNKRNDSM---------------CNSTG-TFVDHGTGARRHCSSINLIKLDSADTDEVLALNEL 597
            .|..|.||:               ..|.| |.::..          :|:....|..|||   .||
  Rat   690 QQGTRKDSVPQVLLPEEEKLIIEETRSNGQTIIEEK----------SLVDTVYALKDEV---KEL 741

  Fly   598 KKES 601
            |:|:
  Rat   742 KQEN 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RtGEFNP_001097184.2 SH3_PIX 6..58 CDD:212810 32/51 (63%)
RhoGEF 79..249 CDD:238091 75/175 (43%)
PH_Cool_Pix 281..376 CDD:269932 37/100 (37%)
Arhgef6XP_008771873.1 CH 29..129 CDD:214479
RhoGEF67_u1 139..184 CDD:293221
SH3_alphaPIX 186..242 CDD:212993 34/54 (63%)
RhoGEF 266..443 CDD:238091 75/176 (43%)
PH_Cool_Pix 474..572 CDD:269932 37/97 (38%)
PH 491..572 CDD:278594 32/80 (40%)
RhoGEF67_u2 598..691 CDD:293220 23/144 (16%)
betaPIX_CC 694..780 CDD:293131 15/65 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4030
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D251777at33208
OrthoFinder 1 1.000 - - FOG0002550
OrthoInspector 1 1.000 - - otm44386
orthoMCL 1 0.900 - - OOG6_103985
Panther 1 1.100 - - LDO PTHR46026
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1675
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.920

Return to query results.
Submit another query.