Protein Alignment RtGEF and Arhgef4

DIOPT Version :9

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_008765203.2
• Gene: Arhgef4 / 301334
• RGDID: 1586179
• Length: 1751
• Species: Rattus norvegicus
• Alignment Length: 517
• Identity: 106/517 - (20%)
• Similarity: 204/517 - (39%)
• Gaps: 122/517 - (23%)

  Fly     8 QAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYV---------------- 56
            :|.:..:..::.||.|:.||||.|....:..||.|.:.|..||||:::|
  Rat  1260 EALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVVDGEGWFPASFVRLRVNQDEPADDYEAP 1324

  Fly    57 --------------NECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEP 107
                          ..||.|:               |:.|:.::|.:||.::..|:.:.|.::..
  Rat  1325 RAGAGEADDSGPEAQSCKDQM---------------RTNVINEILSTERDYIKHLRDICEGYVRQ 1374

  Fly   108 MQQTQ-ILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKV------HQA- 164
            .::.: :.|:::...:..|..:|.|..:..:..:|:       .|.|..|.:.::      |||
  Rat  1375 CRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQ-------KFNTERPHLSELGACFLEHQAD 1432

  Fly   165 ------YCAAHPKAIVILDKYKDELEKY---------MERQ-GAATPGLLVLTTGLSKPFRRLDK 213
                  ||..||.|.|.|.:. .:|.||         ::|. ..:..|.|:      .|.:::.|
  Rat  1433 FQIYSEYCNNHPNACVELSRL-TKLSKYVYFFEACRLLQRMIDISLDGFLL------TPVQKICK 1490

  Fly   214 YSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKEL--ELQVLTGPVRGWQGQELS 276
            |...|.||.::....|.|..:.:.::...|::|...:..:|:.|.  ::......:..|:|::|.
  Rat  1491 YPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLL 1555

  Fly   277 T-LGDIIHMGSVA----VGADHRDRYFVLFPQTLLFLSVS-QRMSAFIYEGKLPLTGIIVNRLED 335
            . ..::||.|.:.    ..|..:.|.|.||.:.|::.... .|.....|:|:|.:..:.|..:||
  Rat  1556 VRSSELIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRDVLYYKGRLDMDDLEVVDVED 1620

  Fly   336 TD------ALKNAFEI-SSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMG---------IKRQ 384
            ..      ::||||.: .....|..:...:.|.:..:|::........:.:.         ::|:
  Rat  1621 GKDRDLHVSVKNAFRLYCGTTGDSHLLCARKPEQKQRWLKAFAREREQVRLDQETGFSITELQRK 1685

  Fly   385 LSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTL-------PPSNY 439
            .:.|:.|.   ..|....:.:...||.||..    :.|.|.. ||.:..|       .|||:
  Rat  1686 QAMLNASK---QQATGKPKAVGRPGYLTRHK----HPSLPAS-RPQQQVLVLAEPRRKPSNF 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	18/79 (23%)
		RhoGEF	79..249	CDD:238091	41/193 (21%)
		PH_Cool_Pix	281..376	CDD:269932	23/106 (22%)
Arhgef4	XP_008765203.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910