Protein Alignment RtGEF and Vav2

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_038960659.1
• Gene: Vav2 / 296603
• RGDID: 1306285
• Length: 873
• Species: Rattus norvegicus
• Alignment Length: 770
• Identity: 148/770 - (19%)
• Similarity: 264/770 - (34%)
• Gaps: 247/770 - (32%)

  Fly    60 KVQLP----LTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYA 120
            :||.|    |||        .:.||..|.::.::|..:...|:.:.:|::.|::  |:||..:.|
  Rat   179 EVQQPMKMGLTE--------DDKRSCCLLEIQETEAKYYRTLEDIEKNYMGPLR--QVLSPVDMA 233

  Fly   121 QLMCNFVEIVRTHEDLLIQIEEC----NDRVGKLFLTSAPLMKKVHQAYCA--AHPKAIV--ILD 177
            .:..|..::::.|...|..|:..    ...:.|:||.....: .::..||:  .|.::.:  :|.
  Rat   234 TIFINLEDLIKVHHSFLRAIDVSMMAGGSTLAKVFLEFKERL-LIYGEYCSHMEHAQSALNQLLA 297

  Fly   178 KYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVY 242
            ...|..:|..|.......|...|...|..|.:|:.||..:|:||..| .:..|:|...:.::...
  Rat   298 SRDDFRQKVEECTLKVQEGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SADRPERQQLKEALEAM 361

  Fly   243 KDIAATCSATRRQKEL------------ELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGA--DH 293
            :|:|...:..:|.||.            .|||           :|...|.....|.:.|.:  :|
  Rat   362 QDLAMYINEVKRDKETLKKISEFQCSIENLQV-----------KLEEFGRPKIDGELKVRSIVNH 415

  Fly   294 --RDRYFVLFPQTLLFLSVSQRMSAFIYE--------------------------GKLPLTGIIV 330
              :|||..||.:.::   |.:| ..:.||                          ||:...|..:
  Rat   416 TKQDRYLFLFDKVVI---VCKR-KGYSYELKEVIELLFHKMTDDPMHNKDIKKSHGKMWSYGFYL 476

  Fly   331 NRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELL------------NANNPSLPMGIKR 383
            ..|:.    |..|:.          .|:..:...||:|..            |||:.|..|....
  Rat   477 IHLQG----KQGFQF----------FCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFD 527

  Fly   384 QLSNLSNSSLGHLNAAHLSQHLDSRGY-CTRFSLCAYYSS----PPCHVRPLRVTLPPSNYPATA 443
            :.:|.....:......:       :|| |||..:.|:...    |||     :::.|..   |.|
  Rat   528 KTTNCKACKMFLRGTFY-------QGYLCTRCGVGAHKECLEVIPPC-----KMSSPAD---ADA 577

  Fly   444 PYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDL-----------KRIALRKRRCHKASAKL 497
            |.|.|......:....|..:...|.:|..|....|:|           .|:...::..:..|:.:
  Rat   578 PGAGLGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLRGDPDSPWWEGRLVQTRKSGYFPSSSV 642

  Fly   498 KDLNTNQD-------------------SGQSELERQDAI------------ELPTDSE------S 525
            |....:..                   :|..|.::.|.:            |.|.::|      .
  Rat   643 KPCPVDGRPPVGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIK 707

  Fly   526 YDDDF-------EDDFLHSCDSDPF----EYVQFYQNKRNDSMCNSTGTFVDHGTGARRHCSSIN 579
            ::|:.       :|.::|..::..|    |.|::||       |:|
  Rat   708 FNDEVKHIKVVEKDSWIHITEAKKFESLLELVEYYQ-------CHS------------------- 746

  Fly   580 LIKLDSADTDEVLALNELKKESLVIGSRALRALARKSTTRNSSVHTSTATLELGVGGSITNCVEE 644
             :|......|..|......:|             |.:|..:|....|.|:.....
  Rat   747 -LKESFKQLDTTLKFPYKSRE-------------RAATRASSRSPASCASYSFSF---------- 787

  Fly   645 EPILKVKP---SFSLQQQSSDASSIFAARLGGAFTACENLASMPDDLSRESSIQE 696
                 :.|   ||:.|..|:...|:|..|:.|...|..|.|:.  |: ||.|::|
  Rat   788 -----LSPQGLSFAPQGPSAPFWSVFTPRVIGTAVARYNFAAR--DM-RELSLRE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810
		RhoGEF	79..249	CDD:238091	40/177 (23%)
		PH_Cool_Pix	281..376	CDD:269932	25/136 (18%)
Vav2	XP_038960659.1	CH_VAV2	2..120	CDD:409112
		RhoGEF	197..369	CDD:459876	38/175 (22%)
		PH_Vav	384..511	CDD:269930	27/155 (17%)
		C1_VAV2	514..571	CDD:410418	15/68 (22%)
		SH3_VAV2_1	585..644	CDD:212913	8/58 (14%)
		SH2_Vav2	662..764	CDD:198269	19/128 (15%)
		SH3_VAV2_2	814..871	CDD:212910	9/24 (38%)