Protein Alignment RtGEF and Plekhg2

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: NP_001402720.1
• Gene: Plekhg2 / 292750
• RGDID: 1310112
• Length: 1345
• Species: Rattus norvegicus
• Alignment Length: 1428
• Identity: 285/1428 - (19%)
• Similarity: 468/1428 - (32%)
• Gaps: 466/1428 - (32%)

  Fly    82 VLKDLLDSERAHVAELQGLLENFLEPMQQTQI--LSQDEYAQLMCNFVEIVRTHEDLLIQIEECN 144
            |.::::::|||:|.:|:.::|::|.|:...:.  |:.::...|..|..:|.....:||..:|.|:
  Rat   103 VAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNVEQVGTLFANIEDIYEFSSELLEDLEGCS 167

  Fly   145 DR--VGKLFLTSAPLMKKVHQAYCAAHPKAIVILDK--YKDELEKYMERQGAATPGLLVLTTGLS 205
            ..  :.:.|:..:... .::..||..:|.::.:|.:  .......:::.:.|.....|.|.:.|.
  Rat   168 SAGGIAECFVQRSEDF-DIYTLYCMNYPSSLALLRELSLSPPATVWLQERQAQLRHSLPLQSFLL 231

  Fly   206 KPFRRLDKYSAMLQELERHMESSHPDRGD---TQRSVAVYKDIAATCSATRRQKE--LELQVLTG 265
            ||.:|:.||..:||||.:|. :..||.|.   .:.::.....:|...:..:|::|  ..||.:..
  Rat   232 KPVQRILKYHLLLQELGKHW-AEGPDTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQR 295

  Fly   266 PVRGWQGQELSTLGDIIHMGSVAVGAD------HRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLP 324
            .:.||.|.|||..|:::..|:...|..      ..:|...||.:.||.  ..:|...:.|:|.:.
  Rat   296 RLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLV--AKRRGPEYTYKGHIF 358

  Fly   325 LTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANK--WVELLN----ANNP-SLPMGIK 382
            ...:.|:   :|......|::|...|.:...:.|..|:..|  |:..|.    .|:| |:|...|
  Rat   359 CCNLSVS---ETPRDPLGFKVSDLTIPKHRHLFQAKNQEEKRLWIHCLQRLFFENHPASIPAKAK 420

  Fly   383 RQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPC------HVRPLRVTLPPSNYPA 441
            :.|  |.||    |:.|..|:|:               ..||.      ..|..|...|....||
  Rat   421 QVL--LENS----LHCAPKSKHI---------------PEPPTSPLDSPRPRDARSFTPSRRNPA 464

  Fly   442 TAPYANLSAHFARLVKGGGLRSAIVK--MLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQ 504
            .:|..:.|..        |.|.:..|  .::.||.    |..::.      |..|
  Rat   465 PSPRLSGSRR--------GRRQSESKDPYVILPQN----DKPQVK------HAGS---------- 501

  Fly   505 DSGQSELERQDAIELPTDSESYDDDFEDDFLHSCDSDPFEYVQFYQNKRNDSMCNSTGTFVDHGT 569
               :.||.....::.|..:....:|.||                    ......:.:||.:
  Rat   502 ---EGELHPPSELQPPVTAPGPPEDLED--------------------AGPPTLDPSGTSI---- 539

  Fly   570 GARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALRALARKS-----TTRNSSVHTSTAT 629
                              |:|:|.|         :..|.||.....:     ..|:|.|...:.|
  Rat   540 ------------------TEEILEL---------LNQRGLRDSGPATHDIPKFPRDSRVPVESET 577

  Fly   630 LELGVGGSITNCVEEEPILKVKPSFSLQQQSSDASSIFAARLGGAFTACENLASMPDDLSRESSI 694
            |......|..:..|||       ...|::...:.|.:...                :.|...|:.
  Rat   578 LPFQALPSRESSEEEE-------DEELEKDEREPSPLHVL----------------EGLEGSSAA 619

  Fly   695 QEPPTP-LPASPTERHSMPTIFVGNRFNHSKNTEVYVPTWRDRQEMQNQSVDAKQDEELHSSSID 758
            :.|..| ||..|::...:|.|                                 .:.....|..|
  Rat   620 EVPCIPSLPKIPSDMPDLPEI---------------------------------PEAPCLPSLSD 651

  Fly   759 LPAA----CL----SAPD--KLQAELLYNYDEILEKPLQ-------LHRELTPFPGHNLN----- 801
            :|..    ||    |.||  .|.....:.....|..|||       ..|||  ..|.||.
  Rat   652 IPGVFEVPCLSPMSSVPDIPSLANTPSFPCGSWLPGPLQEAAQSQATRREL--LTGSNLGRLSEP 714

  Fly   802 -SDKRVSHKSDS-----PSTGNAKTDP------NLATRSSS------------------------ 830
             |:.|...:.|:     |:.......|      .|..||.|
  Rat   715 PSESRAGQEEDTEGVSFPAVQTQDGTPVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLL 779

  Fly   831 ---TTELCIDTTSKKRTTP-SERSRDSIR---RCISYQFLQM--------SNRP----------- 869
               .::|...:||.|...| ||||...:|   |..|.:..||        :|.|
  Rat   780 ILEDSDLSGGSTSGKTRMPHSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVLAQPQ 844

  Fly   870 PPPPPPRRDPD------------LHLDTKCRCCENS---------QCPSPRSSDSGMAGSCTITS 913
            |.|.||:.:.:            ..|.....|.:.|         |..:|..:........::|.
  Rat   845 PCPCPPQEEAEPGALPAFGHVLVCELAFPLNCAQESVPLGPAALVQAATPLCTQGDDLSGQSLTV 909

  Fly   914 PDPPNPESYFPMEAAGHDMLDNVEPERFDVCGMFR-EKFLTPEAT----QDVVDLSEEQPQLSDE 973
            .|.|.         .|| :.:|..|....:.|... :....|.|:    ||..|:     ||...
  Rat   910 SDLPK---------QGH-LSNNCIPPPVPLPGQSNFQSLQVPSASLLPKQDPPDV-----QLPTA 959

  Fly   974 PTTP-TNRKEEPTCITSA--------QVQVNTRSI---------FLPSSSSM--DETNRNVPANN 1018
            .|.| |.:.:.|....|.        |||..|.|:         .:|:::::  .|.:.:..:.|
  Rat   960 STLPDTGQLQVPAAAPSTEHRNYVEIQVQSTTTSLPGQECPADFQMPTTAALPRQEGHEDSRSPN 1024

  Fly  1019 ILFSSSSADQ----------------LEPQATFRSGMYAHWWKKERLP--PEV--VRGIAHAYNK 1063
               |:..|:|                :.|.....|....|......||  |::  :.|..
  Rat  1025 ---SAPGAEQRDVGVDQGPTAVDGQAVSPLPACTSSPDHHQIPATPLPLSPDLPDMEGAG----- 1081

  Fly  1064 SLPSKDSKDSGSVCSSC--FCSLGASGYSEGALYCSVCQNCADY----------------YNG-- 1108
            :||....:.....|..|  ..||.....:...:..|..|...|.                :.|
  Rat  1082 ALPLPAQQGHPDCCVPCDPLPSLPQDVQTPTVIPMSQPQGLTDVRAKVPPSFPTQEEAPEFLGPE 1146

  Fly  1109 -SVTST-----------TNTT---TTTSSASCPL--CSED-EGMI-APTHDSSSLDCPICNGRIA 1154
             |:|.|           .|||   .:|::..||.  |.:| :|:| :|.  .::::.|...|.::
  Rat  1147 PSLTDTPAPRLLPSSGQQNTTDGHVSTAAVPCPEQGCPQDIQGLITSPV--QTTMELPKPRGLVS 1209

  Fly  1155 SGAEEGKQSEMDRRPDVAAIKPHTPT--------------ARRPSASHSQQHPGRQQQRREPQPP 1205
            ..|   ....:|..|      ||:|:              :|..:||:..|...|:      |.|
  Rat  1210 RVA---TSESLDLTP------PHSPSLSTRQLLGPSAAALSRYLAASYISQSLARR------QGP 1259

  Fly  1206 GVSGHQLDVASQ--------TEPVVQPPSQLQSVHAHSASTTSSASTTTTKSAKSSGG--IRP 1258
            |..|.   .|||        |.....||.|.|.    .|......|..||.|.:..||  :||
  Rat  1260 GGEGM---AASQGHWSSSAPTSRAPSPPPQPQP----PAPPARRLSYATTVSIQVGGGGRLRP 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810
		RhoGEF	79..249	CDD:238091	40/175 (23%)
		PH_Cool_Pix	281..376	CDD:269932	22/107 (21%)
Plekhg2	NP_001402720.1	RhoGEF	103..278	CDD:459876	40/176 (23%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	32/154 (21%)
		PHA03247	<431..687	CDD:223021	65/408 (16%)
		PHA03247	<668..1236	CDD:223021	117/603 (19%)