DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and MCF2L

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_011535788.2	Gene:	MCF2L / 23263	HGNCID:	14576	Length:	1238	Species:	Homo sapiens

Alignment Length:	689	Identity:	138/689 - (20%)
Similarity:	239/689 - (34%)	Gaps:	212/689 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQ---QTQILS---QDEYAQLMCNFVEIVR 131
            |.:...|..|:.:|||:|||:|.||..:||.:...|.   ...:||   .::...|..|..||..
Human   653 ESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYH 717

  Fly   132 THEDLLI-QIE---ECNDRVGKLFLTSAPLMK--KVHQAYCAAHPKAIVILDKYKD-----ELEK 185
            .|..:.: ::|   :|.:.||:.||..   |:  ::::.||...|::..:..:..|     |.::
Human   718 FHNRIFLRELENYTDCPELVGRCFLER---MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQR 779

  Fly   186 YMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQEL---ERHMESSHPDRGDTQRSVAVYKDIAA 247
            .::.:       |.|.:.|.||.:|:.||..:|:|:   .|:.|.:.    |.|.:::....|..
Human   780 KLDHK-------LSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAE----DLQEALSSILGILK 833

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHR---------------DRY 297
            ..:     ..:.|..:|    |:.| .|..||.::..||.:|..||:               .|:
Human   834 AVN-----DSMHLIAIT----GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRH 888

  Fly   298 FVLFPQTLLFLSVS-------QRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVA 355
            ..|..:.:||....       ::..::.|:..|.:..:.:......||.|  |||.
Human   889 LFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKK--FEIW--------- 942

  Fly   356 VCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSSLGHLNAAHLSQH---------------- 404
                 ..|.:.|.::.|..|.:......::..:..|.|.....|  |||
Human   943 -----YNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREA--SQHRALEQSQSLPLPAPTS 1000

  Fly   405 -LDSRGYCTR-----------FSLCAYYSSPPCHVRPLRVTLPPSNYPATAPYANLSAHFARLVK 457
             ..|||....           .||..|.||.|       :|.||..
Human  1001 TSPSRGNSRNIKKLEERKTDPLSLEGYVSSAP-------LTKPPEK------------------- 1039

  Fly   458 GGGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQDSGQSELERQDAIELPT- 521
              |....:..     .|.:|..|.    |||...:..|.||....:..|...:.:|.:....||
Human  1040 --GKDDTVTS-----SASESSALS----RKRFTLQGFANLKGQKASPTSPDKKAKRHEVKSDPTP 1093

  Fly   522 -----------DSESYDDD----FEDDFLHSCDSD-----------PFEYVQFYQNKRNDSMCNS 560
                       ..|:.:||    ..::.::|.|::           |.:|.
Human  1094 FGVRGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYT-------------- 1144

  Fly   561 TGTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALRALARKSTTRNSSVHT 625
              ...||..|..      :.:::.|.|      :.||.:|    |...|..:...:|.:...|..
Human  1145 --VVADHEKGGP------DALRVRSGD------VVELVQE----GDEGLWYVRDPTTGKEGWVPA 1191

  Fly   626 STATLELGVGGSITNCVEEEPILKVKPSFSLQQQSSDAS 664
            |:.::.||..|| ..|:...   :..|..::...||..|
Human  1192 SSLSVRLGPSGS-AQCLSSS---ESSPGSAVLSNSSSCS 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810
		RhoGEF	79..249	CDD:238091	48/189 (25%)
		PH_Cool_Pix	281..376	CDD:269932	20/116 (17%)
MCF2L	XP_011535788.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910